Coagulants, homeostatics

To prevent and stop bleeding, use tools that increase blood clotting (gemostatiki). Hemostatic agents presents a drugs of different groups and different mechanism of action.

Topically to stop the capillary and parenchymal bleeding apply the Thrombin (product of natural thrombin) and other local gemostatiki (hemostatic sponge with ambenom, hemostatic collagen sponge, etc.) that provides not only hemostasis, but also antiseptic properties that promote tissue regeneration and wound healing.

The hemostatic General (systemic) action refers To the vitamin and its homologues, menadione sodium bisulfite, etc. (see VITAMINS AND VITAMIN-like SUBSTANCES). Vitamin K is called protivogemorragicheskim or coagulation vitamin because it is involved in the biosynthesis of prothrombin complex (prothrombin and factors VII, IX and X) and promotes normal blood clotting. When deficiency of vitamin K develop hemorrhagic phenomena.

To normalize blood clotting in patients with hemophilia, as well as violations of hemostasis caused by circulating inhibitors of blood coagulation factors, use special preparations containing various coagulation factors (factor VIII, antihemophilic, etc.). In some cases, reduction of bleeding also used extracts and tinctures of vegetable raw materials (nettle leaves, grass yarrow, shepherd's purse, water pepper, etc.).

A specific antagonist of heparin that contribute to the normalization of blood clotting when overdose is Protamine sulfate. Its mechanism of action is associated with the formation of complexes with heparin.

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