The General concreting effect on the Central nervous system has a number of means, mainly of plant origin. In addition to non-specific General-tonic effect on the Central nervous system, these drugs improve endocrine regulation and metabolism, as well as increase the body's adaptation to adverse factors.
Complexes of biologically active substances levzei, Chinese Magnolia vine, zamanihi, aralia have obsecenities action. Preparations of ginseng, Eleutherococcus, Rhodiola rosea and other plants combine the General toning effect with adaptive properties.
The mechanism of General and adaptogenic action remains unclear. It is assumed that in the implementation of adaptogenic action plays a role of strengthening the adaptive synthesis of RNA and proteins, the activity of enzymes of energy metabolism and regeneration processes.
The spectrum of action of General means includes first of all the General effect, which develops gradually and is expressed in an increase in the tone and functioning of the body. Activation of metabolism, endocrine and vegetative regulation is the basis of the General-toning action. General concreting effect is accompanied by increased appetite, increased tone of hollow organs, secretion of gastrointestinal glands. In addition to these effects, there is a restoration of reduced vascular tone, a slight increase in blood PRESSURE and heart function. In addition obscenities for drugs in this group prakaran not pronounced psychostimulant effect. Psychostimulation is manifested in improving performance (physical and mental), reducing the signs of asthenia and fatigue. This effect is not accompanied by signs of excitation, including euphoria. It should be noted that the manifestation of both General and psychostimulating effects is in the range of physiological norm.
Preparations obtained from plants with adaptogenic action have a slight psychostimulatory effect (the severity and speed of development is much inferior to psychostimulants and General-tonic drugs). The main effects in the pharmacodynamics of adaptogens are the following:
- stimulation of immunity (specific and non-specific) and increase of resistance to infection. This is based on the use of adaptogens during epidemics, leading to a decrease in the number of patients and the severity of the clinical picture of the disease;
- improving the body's tolerance of adverse environmental factors (high and low ambient temperature, intoxication, radiation, etc.).
As drugs obstensibly funds and use different adaptogens extracts of of medicinal herbs: tinctures, liquid extracts, etc. However, the most strong and selective obsecenities action have isolated alkaloids — strychnine, securinine, Echinopsis. These alkaloids are highly toxic and therefore are not practically used.
General concreting agents and adaptogens are low-toxic and usually well tolerated. Do not assign them with increased excitability of the Central nervous system, hypertension and some other conditions.
Shown General tonic remedies and adaptogens for fatigue (after trauma, systemic diseases, etc.), prealablement, hypotension, to boost the immunity during epidemics. These drugs are effective for maintaining General tone and efficiency, including in elderly patients, and for accelerating adaptation (physical and mental overload, changes in living and working conditions, the influence of adverse factors). It should be borne in mind that adaptogens are preventive means, i.e. their effect is manifested in long-term systematic use.
Sources of General and adaptogenic agents are not only plants. They are derived from neokostenelyh horns of elk and deer (Pantocrine and others), aquatics or synthetically — acetylaminosiccine acid, sulbutiamine etc.
It should be noted that some drugs of other pharmacological groups (bendazol, etc.), as well as a large number of drugs of complex composition, including the above drugs, have a General-ionizing and adaptogenic effect.