Normotimics (temozolamide) — drugs that may lead to smooth circular disorders of the affective sphere (mood swings), and for prophylactic use to prevent the development of depressive and manic symptoms in the framework of schizoaffective disorder, bipolar disorder, recurrent depressive disorder and chronic mood disorders. All have also Normotimics antimaniakalny pronounced effect and is used to treat manic States. To drugs Normotimics action of the salts of lithium, "small" anticonvulsants (derivative of carbamazepine and valproic acid).
The indications of Normotimics is the prevention of relapse in bipolar and depressive disorders, cyclothymia, schizoaffective psychosis. They are used in manic and hypomanic States of different origin, affective disorders in patients with chronic alcoholism. Normotimics therapy is indicated if for the last 2 years, the patient noted at least two clear affective attacks. The lack of effectiveness of preventive monotherapy used a combination of salts of lithium with anticonvulsants. Prophylactic therapy indefinitely long period of time (years).
Abrupt cessation of reception of Normotimics can lead to quick resumption of affective fluctuations. Given this, the abolition of preventive therapy is carried out gradually over several weeks. Prior to withdrawal of the drug, the patient should be warned of the possibility of deterioration.