Expiration date: 02/2026

Composition and form of issue:

1 tablet contains amlodipine (in the form of besilate) 5 or 10 mg in a contour cell pack of 10 PCs., in a cardboard pack of 1 or 3 packages.

Pharmacological action:

Blocks the flow of calcium ions through the membrane in the smooth muscle cells of the myocardium and vessels (calcium channels). Vasodilatation leads to a decrease in blood PRESSURE. The antianginal effect is due to both a decrease in oxygen consumption, due to the expansion of arterioles and a decrease in OPSS (postnagruzki), and an increase in oxygen delivery due to the dilation of the main coronary arteries and arterioles in the ischemic and unchanged areas of the myocardium.

Pharmacokinetics:

After introduction inside (food intake does not affect absorption) in therapeutic doses is well resorbed, reaching a Cmax in the blood after 6-12 h. the Absolute bioavailability is 64-80%. T1/2 — 35-50 h. Biotransformiroetsa in the liver to form inactive metabolites. Urine is excreted 10% unchanged drug and 60% metabolites.

Indications:

Arterial hypertension (means the first row for monotherapy or in combination with other hypotensive drugs), stable angina pectoris, vasospastic angina (Prinzmetal or variant angina), vasospasm/vasoconstriction, dilated (non-ischemic) cardiomyopathy with severe chronic heart failure (stages III-IV) and patients refractory to treatment with nitrates or beta-blockers (monotherapy or in combination with other antianginal drugs).

Contraindications:

Hypersensitivity (including to other dihydropyridines), hypotension, childhood.

Use during pregnancy and breast-feeding:

Not recommend.

Side effect:

Headache, edema, fatigue, somnolence, nausea, abdominal pain, flushing, palpitations and dizziness, rarely — dyspepsia, arthralgia, asthenia, dyspnea, gingival hyperplasia, gynecomastia, impotence, increased frequency of urination, mood changes, muscle cramps, myalgia, pruritus, rash, visual disturbances, rarely — erythema multiforme, jaundice, and elevated liver transaminases.

Dosage and administration:

Inside. In hypertension and angina pectoris initial dose-5 mg / day if necessary, the dose is increased to 10 mg/day. Patients with dilated cardiomyopathy treatment begins with a dose of 2, 5 mg / day, increasing it with good tolerance to 10 mg / day. The maximum daily dose - 10 mg. dose Adjustment while taking with ACE inhibitors, beta-blockers, thiazide diuretics is not required.