Expiration date: 01/2026
Composition and form of release:
Tablets 1 tablet:
captopril 25 mg
in a contour cell pack of 10 PCs. in a pack of cardboard 2 or 4 packages, or in a plastic bag 5000 PCs. there is 1 plastic bag in the Bank.
Tablets 1 tablet:
captopril 50 mg
in a contour cell pack of 10 PCs. in a pack of cardboard 2 or 4 packages, or in a plastic bag 5000 PCs. there is 1 plastic bag in the Bank.
Dosage and administration:
Inside 1 hour before meals. The dosage regimen is set individually.
With arterial hypertension, treatment begins with the lowest effective dose — 12, 5 mg 2 times a day (rarely — 6, 25 mg 2 times a day). You should pay attention to the tolerance of the first dose during the first hour. If arterial hypotension develops, the patient should be moved to a horizontal position (such a reaction to the first dose should not serve as an obstacle to further therapy). If necessary, the dose is gradually increased (at intervals of 2-4 weeks) until the optimal effect is achieved. For mild or moderate arterial hypertension, the usual maintenance dose is 25 mg 2 times a day, the maximum dose is 50 mg 2 times a day. In severe hypertension, the maximum dose is 50 mg 3 times a day. The maximum daily dose is 150 mg.
In elderly patients, the initial dose is 6, 25 mg 2 times a day.
In heart failure, a combination with diuretics and/or digitalis drugs is possible (to avoid an initial excessive decrease in blood PRESSURE, before prescribing Captopril, the diuretic is canceled or the dose is reduced). The initial dose is 6, 25 mg or 12, 5 mg 3 times a day, if necessary, the dose is increased to 25 mg 3 times a day. The maximum daily dose is 150 mg.
If the left ventricle function is impaired after a myocardial infarction in patients who are in a clinically stable condition, the use of Captopril can be started as early as 3 days after a myocardial infarction. The initial dose is 6, 25 mg per day, then the daily dose can be increased to 37, 5-75 mg in 2-3 doses (depending on the tolerability of the drug). If necessary, the dose is gradually increased to the maximum daily dose of 150 mg/day. With the development of arterial hypotension, it may be necessary to reduce the dose.
In diabetic nephropathy, a daily dose of 75-100 mg is prescribed for 2-3 receptions. In insulin-dependent diabetes with microalbuminuria (albumin release 30-300 mg/day), the dose of the drug is 50 mg 2 times a day. With a total protein clearance of more than 500 mg per day, the drug is effective at a dose of 25 mg 3 times a day. With a moderate degree of renal impairment (creatinine Cl — at least 30 ml/min/1, 73 m2), Captopril can be prescribed at a dose of 75-100 mg/day. With a more pronounced degree of renal dysfunction (creatinine Cl-less than 30 ml / min/1, 73 m2), the initial dose should not exceed 12, 5 mg/day in the future, if necessary, the dose is gradually increased through fairly long intervals, but use a lower than in the case of treatment of hypertension, the daily dose of the drug.
If necessary, additionally prescribe loop (but not thiazide) diuretics.
Storage conditions:
(protect from moisture).
