Expiration date: 03/2026
Packaging and release form
Powder for the preparation of a solution for external use.
Approximately 1.30 g of erythromycin and 0.39 g of zinc acetate dihydrate in a 30 ml bottle made of high-density polyethylene with a screw cap.
8.36 ml of diisopropyl sebacate and 21.6 ml of ethanol in a 30 ml bottle made of high-density polyethylene with a screw cap.
1 bottle of powder A and 1 bottle of solvent B, together with a dosing applicator equipped with a sponge made of viscose and polyester, and instructions for medical use in a cardboard pack.
Composition
The packaging of the drug consists of two vials, one of which contains active ingredients in powder form, and the other - auxiliary substances in solution form.
The composition of the powder bottle (bottle A)
Active ingredients: Erythromycin 1200 mg; Zinc acetate dihydrate (micronized) 360 mg.
The composition of the solvent bottle (bottle B)
Excipients: Diisopropyl sebacate 7.81 g (8.36 ml); Ethanol 17.1 g (21.6 ml).
1.0 ml of the prepared preparation contains:
Active ingredients:
Erythromycin 40.0 mg; Zinc acetate dihydrate (micronized) 12.0 mg.
Auxiliary substances:
Diisopropyl sebacate 0.25 g; Ethanol 0.55 g.
Dosage form
Description of the reconstituted solution
A clear, colorless to cloudy solution.
Pharmacotherapeutic group
acne rash treatment
Pharmacodynamics
Zineryt - erythromycin-zinc complex.
It has anti-inflammatory, antimicrobial and comedonolytic effects.
Erythromycin acts bacteriostatically on the microorganisms that cause acne: Propionibacterium acne and Streptococcus epidermidis.
Zinc reduces the secretion of sebaceous glands, has an astringent effect.
Pharmacokinetics
The complex connection of the components of the drug ensures good penetration of active substances into the skin.
Zinc mainly binds to the follicular epithelium and is not resorbed into the systemic bloodstream.
A small part of erythromycin undergoes systemic distribution and is subsequently excreted from the body.
Indications
Acne treatment.
Contraindications
- Hypersensitivity to erythromycin and other macrolides;
- hypersensitivity to zinc.
Use during pregnancy and lactation:
Currently, it has been established that it is possible to use the drug during pregnancy and lactation (breastfeeding) according to the recommended doses.
Method of administration and dosage
Externally.
Using the supplied applicator, Zinerit® is applied in a thin layer to the affected area of the skin 2 times a day: in the morning (before applying makeup) and in the evening (after washing). The drug should be applied by tilting the vial with the prepared solution downwards, with light pressure. The rate of application of the solution is regulated by the pressure of the applicator on the skin.
An approximate single dose is 0.5 ml. After drying, the solution becomes invisible.
The course duration is 10-12 weeks. In some cases, clinical improvement is possible after 2 weeks.
Special instructions
The possibility of developing cross-resistance to other macrolides, lincomycin, and clindamycin should be considered.
It is necessary to avoid contact with the eyes, on the mucous membrane of the mouth and nose (possible irritation or burn).
Side effects
Local reactions: sometimes there may be a burning sensation, irritation, dryness of the skin at the site of application of the drug (as a rule, these phenomena are mild and do not require discontinuation of the drug and / or symptomatic therapy).
Drug interaction
To date, no clinically significant interactions of Zinerit® with other drugs have been established.
Dosage form
Description of the reconstituted solution
A clear, colorless to cloudy solution.
Pharmacotherapeutic group
acne rash treatment
Pharmacodynamics
Zineryt - erythromycin-zinc complex.
It has anti-inflammatory, antimicrobial and comedonolytic effects.
Erythromycin acts bacteriostatically on the microorganisms that cause acne: Propionibacterium acne and Streptococcus epidermidis.
Zinc reduces the secretion of sebaceous glands, has an astringent effect.
Pharmacokinetics
The complex connection of the components of the drug ensures good penetration of active substances into the skin.
Zinc mainly binds to the follicular epithelium and is not resorbed into the systemic bloodstream.
A small part of erythromycin undergoes systemic distribution and is subsequently excreted from the body.
Storage temperature
from 15℃ to 25℃
Overdose
Accidental overdose is unlikely due to the peculiarities of topical application of the drug.
Special storage conditions
Shelf life: the prepared solution is 5 weeks. Do not use after the expiration date
