Expiration date: 01/2025
Active substance: Furosemide
Structure and Composition
1 tablet contains 40 mg of furosemide; 45 tablets in box.
One 2 ml ampoule with an injection - 20 mg.
Pharmachologic effect: diuretic.
Blocks the reabsorption of sodium and chloride in the ascending loop of Henle knee. It increases excretion of potassium, calcium, magnesium.
Pharmacokinetics
When ingestion bioavailability is 64%. Cmax increased with increasing dose, but the time did not achieve maximum dose-dependent and varies widely depending on the condition of the patient. T1 / 2 -. About 2 h 91-99% associated plasma protein, 2,4-4,1% is in the free state. Biotransformiroetsa, mainly in the glucuronide. Return with urine (after the on / in more than ingestion).
Clinical pharmacology
Starting diuretic effect ingestion is observed within 1 hour, most of action - in 1-2 hours duration -. 6.8 h on / in the introduction of onset of action - 5 min, max - 30 minutes duration - about 2 hours. The on / in the introduction causes varicose veins, quickly reducing preload reduces the pressure in the left ventricle and the pulmonary artery, reduces the system pressure.
Testimony
Edematous syndrome of various genesis (heart, liver, kidney after the second month of pregnancy, intoxication), lung and brain edema, hypertension, forced diuresis, renal failure.
Contraindications
Hypersensitivity (including to other. Sulfon- and sulfonamides), acute glomerulonephritis, renal failure with anuria, hepatic coma, disruption of water and electrolyte balance and acid-base balance (hypokalaemia, hyponatraemia).
Pregnancy and breast-feeding
If pregnancy should be used under strict indications and only for a short time. At the time of treatment is necessary to suspend breastfeeding.
Side effects
Hypotension, arrhythmia, dry mouth, nausea, vomiting, diarrhea, pancreatitis, hypovolemia, dehydration, hypokalemia, hyponatremia, hyposalemia, metabolic alkalosis, hypocalcemia, hyperuricemia, dermatitis, hearing loss, vision, paresthesia, dizziness, muscle weakness, urinary retention in patients with BPH, hypercholesterolemia, hypertriglyceridemia, impaired glucose tolerance, acute pancreatitis, and allergic reactions (rash, fever, vasculitis, interstitial nephritis); in preterm infants - nephrocalcinosis.
Interaction
It increases the risk of cardiac glycoside intoxication (in the background of glucocorticoids probability hypokalemia), nephrotoxicity and ototoxic effects of aminoglycosides, cephalosporins, cisplatin; enhances the effect of curariform funds; increase lithium reabsorption in the renal tubules. NSAIDs reduce the diuretic effect.
Dosing and Administration
Inside, usually assigned on an empty stomach; I / administered for at least 1-2 min. With a mild hydropic syndrome initial dose for adults - 20-80 mg when taken orally or 20-40 mg / in; in the case of persistent edema - the same or increased by 20-40 mg (20 mg for parenteral administration) dose may be reappointed no earlier than 6-8 hours (2 hours for parenteral administration) until a diuretic effect; such individually selected dosage can be used 1 or 2 times a day. Maximum efficiency is achieved when taking 2-4 days per week of the drug. For children, the initial dose - 2mg / kg body weight (for parenteral administration - 1 mg / kg), may be unsatisfactory in effect increased by 2.1 mg / kg (when administered parenterally - 1 mg / kg), but not before than 6-8 h (for parenteral administration, this term - at least 2 hours). When hypertension initial dosage for adults - 80 mg per day in 2 divided doses. Pulmonary edema Lasix administered in / 40mg, if necessary after 20 minutes, the introduction of the drug at a dose of 20 to 40 mg.
Precautionary measures
It is necessary to take into account a possible reduction in the rate of reaction (cautiously prescribe when driving and maintenance arrangements).
Storage conditions
In the dark place at a temperature no higher than 25 ° C.
Keep out of the reach of children.
The shelf life of the drug Lasiks®: 3 years.
Do not use beyond the expiration date printed on the package.
