Drugs in this group reproduce the effects of the mediator of the parasympathetic nervous system — acetylcholine, due to its interaction with m-cholinergic receptors. m-cholinergic Receptors localized in all organs receiving parasympathetic innervation, in the end the postganglionic parasympathetic fibers. the muscarinic Receptors are heterogeneous. The interaction with M1-cholinergic receptors of the CNS is accompanied by the appearance of arousal, and M1-receptors in the intramural parasympathetic plexus of the gastrointestinal tract — increased secretion glands of the gastrointestinal tract.
The effect of activation of the m2 cholinergic receptors, localized in the heart, manifested in the reduction of heart rate and other heart functions, including conductivity.
The most numerous effects of m-cholinomimetics, caused by excitation of m3-cholinergic receptors of smooth muscles and exocrine glands. They cause bronchoconstriction and branchereau, increasing the secretion of the gastric glands, increase the tone of blood, jelche - and urinary tract. The effect of aceclidine on the gastrointestinal tract can be used in atony bowel and bladder.
The most relevant aspect of the pharmacodynamics of m-cholinomimetics is their effect on intraocular pressure: they improve the outflow of intraocular fluid, thereby lowering intraocular pressure. This effect is used in the treatment of intraocular hypertension and glaucoma.