Expiration date: 11/2025

The composition and form of issue:

Capsule. 1 capsule contains:

paracetamol 200 mg

ascorbic acid 150 mg

caffeine 25 mg

hlorfeniramina maleate 2.5 mg

excipients: lactose monohydrate magnesium sulphate heptahydrate tristearate gelatin 

the composition of the capsule shell: 

shell — gelatine water titanium dioxide 

cap — gelatin quinoline yellow water, the yellow dye "sunset" titanium dioxide 

blistere in 10 PCs in the paper cartons 1 or 2 blisters.

Description pharmaceutical form:

Opaque hard gelatin capsules size No. 1, cap yellow, body is white. The contents of capsules — powder from white to yellowish.

Pharmacological action:

Analgesic, antipyretic.

Pharmacokinetics:

Combination drug for symptoms of colds.

Paracetamol has analgesic (painkiller) and antipyretic activity (influence on the thermoregulation center in the hypothalamus).

Ascorbic acid is involved in the regulation of redox processes, carbohydrate metabolism, clotting of the blood, regeneration (recovery) tissues, in the synthesis of steroid hormones increases the body's resistance to infections, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, Pantothenic acid. Improves tolerability of paracetamol and extends its action (slower elimination).

Caffeine has antispasmodic (relaxing) activity, dilates the bronchi, stimulates the brain vessels, stimulates the heart, has a tonic effect.

Chlorpheniramine — an antihistamine, antiallergic action: it reduces isolation and nasal congestion, watery eyes, sneezing.

The combination components of the drug provides better portability of the symptoms of malaise and fever the disease anemia and other respiratory diseases.

Paracetamol has analgesic (painkiller) and antipyretic activity.

Ascorbic acid is involved in the regulation of redox processes, carbohydrate metabolism, clotting of the blood, regeneration (recovery) tissues, in the synthesis of steroid hormones increases the body's resistance to infections, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, Pantothenic acid. Improves tolerability of paracetamol and extends its action (ease of removal).

Indications:

• febrile syndrome in infectious and inflammatory diseases
  
• syndrome pain of moderate or mild severity (headache, migraine, toothache, neuralgia, myalgia, arthralgia, algomenorrhea (a painful irregular menstruation).
  

Contraindications:

• hypersensitivity to the drug
  
• gastrointestinal bleeding
  
• portal hypertension (increased blood pressure in the portal vein)
  
• alcoholism
  
• pronounced hepatic and/or renal failure
  
• pregnancy (I and III trimenon)
  
• breastfeeding
  
• children's age (under 15 years)
  
• the deficit glukozo-6-fosfatdegidrogenaza
  
• angle-closure glaucoma
  
• hypertrophy of the prostate gland with formation of residual urine
  
• severe arrhythmia
  
• uncontrolled hypertension.
  

With caution:

• erosivno-azwenne shock syndrome (in the acute phase)
  
• hepatic and/or renal failure
  
• congenital hyperbilirubinemia (diseases in which elevated levels of bilirubin in the blood, syndromes of Gilbert's, Dubin-Johnson and Rotor).
  

With caution:

• diabetes
  
• pheochromocytoma
  
• Coronary artery disease (angina)
  
• prostatic hyperplasia
  
• thyrotoxicosis
  
• the period of breastfeeding.
  

Application of pregnancy and breast-feeding:

Contraindicated in pregnancy (I and III trimester) and lactation.

Side effects:

In therapeutic doses the drug is generally well tolerated. Sometimes there allergic skin reactions (skin rash, itching, hives, angioedema) gastrointestinal dysfunction (nausea, epigastric pain, dry mouth) or difficulty urinating.

Rarely violations of the blood system (anemia, leukopenia — decreased content of leukocytes in the blood, thrombocytopenia — reduced platelet count in the blood).

Long-term use in high doses (more than 12 caps. daily for more than 5 days) — hepatotoxic effects, disorders of the blood system erosivno-azwenne shock syndrome nephrotoxicity (papillary necrosis).

Drug interactions:

Stimulants microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which determines the possibility of severe intoxications with small overdoses.

Inhibitors mikrosomalnogo oxidation (cimetidine) reduce the risk of hepatotoxicity of the drug.

Ethanol contributes to the development of acute pancreatitis.

Reduces efficiency urikozuricheskih LS.

By reducing the speed of gastric emptying (propantheline) slows down the action of the drug, with faster (metoclopramide), begins to act faster.

Increases toxicity of chloramphenicol.

Can strengthen action of indirect anticoagulants

Method of application and dose:

Inside, squeezed small amounts of liquid, 2 caps. at the reception. If necessary, repeat the same dose after 4-6 hours, 3-4 times a day. The maximum daily dose should not exceed 12 caps.

Overdose:

Symptoms: (due to paracetamol): pallor, loss of appetite, nausea, vomiting gepatonekros (the severity of necrosis due to intoxication, directly depends on the extent of overdose). Toxic effect in adults is possible after reception over 10-15 g of paracetamol.

Treatment: the introduction of aid donors SH-groups and precursors of glutathione-methionine via 8-9 hours after the overdose and N-acetylcysteine — through 12 h.

The need for additional therapeutic measures (further introduction of methionine, in/in the introduction of N-acetylcysteine) is determined depending on concentration of paracetamol in the blood, and the time elapsed after its reception.

Special instructions:

During hyperthermia, lasting more than 3 days, and duration of a painful syndrome more than 5 days requires a doctor's consultation.

Ascorbic acid, part Grippostad With and Grippostad, distorts the results of laboratory tests, evaluating concentration of glucose and uric acid in plasma.

Should not simultaneously use other drugs, containing paracetamol, as well as other non-narcotic analgesics and NSAIDs (Metamizole, acetylsalicylic acid, ibuprofen, etc.) and barbiturates, antiepileptic drugs, rifampicin, chloramphenicol. The simultaneous use of other drugs should be agreed with your doctor.

With prolonged (more than 5 days) use of the drug needed to be monitored picture peripheral blood and functional state of the liver.

People prone to alcohol consumption, before the beginning of treatment to consult a doctor as acetaminophen can have a damaging effect on the liver.