Expiration date: 01/2026

Pharmacokinetics:

When applied to the skin and mucous membranes, systemic absorption is minimal and practically insignificant.

Description of pharmacological action:

Ribavirin triphosphate (RTF) is a potent inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase), viral RNA polymerase, and viral mRNA guanylyltransferase. Inhibition of the latter stops mRNA capping, which leads to a significant depletion of intracellular reserves of guanosine triphosphate and inhibition of viral RNA and protein synthesis. Ribavirin is also embedded in the viral genome, causing lethal mutations, followed by a decrease in the pathogenicity of the virus. Ribavirin inhibits the replication of new virions, which reduces the viral load, selectively inhibits the synthesis of viral RNA, without suppressing the synthesis of RNA in normally functioning cells. The most sensitive to ribavirin DNA viruses-herpes simplex virus, adenoviruses, CMV, smallpox viruses, Marek's disease RNA viruses — viruses of influenza A, B, paramyxoviruses (parainfluenza, mumps, Newcastle disease), reoviruses, arenaviruses (Lassa fever virus, Bolivian hemorrhagic fever), bunyaviruses (rift Valley fever virus, Crimea-Congo hemorrhagic fever virus), Hantaviruses (hemorrhagic fever virus with renal or pulmonary syndrome), oncogenic RNA viruses.

Ribavirin-insensitive DNA viruses: Varicella zoster, pseudo-rabies virus, natural cowpox RNA viruses: enteroviruses, rhinoviruses, encephalitis virus, Semliki.

Indications:

The cream can be used as a monotherapy or in combination with other medicinal forms of ribavirin intended for parenteral and oral use in the following diseases:

• infections of the skin and mucous membranes caused by Herpes simplex viruses of the 1st and 2nd types, of different localization, including in the genital area
• herpes zoster (as part of complex therapy).

Contraindications:

• hypersensitivity to ribavirin or other components of the drug
• pregnancy
• lactation
• children and youth (up to 18 years).

With caution: renal insufficiency is used in women and men of reproductive age.

Use during pregnancy and lactation:

The use of the cream during pregnancy and lactation is contraindicated.

Side effect:

Possible allergic reactions (skin rash, urticaria, exanthema).

Other: hair loss, changes in TSH content, symptoms of autoimmune diseases (extremely rare).

The observed effects are usually reversible, do not affect the effectiveness of treatment and stop after the end of treatment.

Drug interaction:

It is not revealed.

Dosage and administration:

Externally, apply to the affected areas of the skin and mucous membrane (pre-washed and dried) in a uniform thin layer, lightly rubbing.

Apply 5 times a day until the complete disappearance of symptoms.

If there is no improvement within 8 days of use, stop taking the drug and consult a doctor.

To get the best effect, treatment should be started as early as possible at the first appearance of symptoms.

If Devirs cream is prescribed in combination with one of the medicinal forms of ribavirin for oral or intravenous administration, the dose of the cream should be reduced.

Special instruction:

Do not use for the treatment of ophthalmic herpes, do not apply in the eye area.

The drug should be used with extreme caution in patients with renal failure.

Men and women of reproductive age should use effective contraceptives during treatment and for 7 months after the end of therapy.