Expiration date: 03/2026
Dosage:
Pharmaceutical action. Combo of drugs that provide analgesic and anti-inflammatory effect. Paracetamol has antipyretic and analgesic effect. Non-narcotic analgesic, blocks TSOG1 and TSOG2 mainly in the Central nervous system, affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains the almost complete absence of anti-inflammatory effect. Ascorbic acid plays an important role in the regulation of oxidation-reduction processes, carbohydrate metabolism, blood coagulation, tissue regeneration, increases the body's resistance. Diphenhydramine has antihistamine and anti-inflammatory, soothing and hypnotic effect. Calcium gluconate is a regulator of calcium and phosphorus metabolism. Rotatin reduces the permeability and capillary fragility, has antioxidant properties.
Indications. Hyperthermia in colds and other infectious and inflammatory diseases.
Contraindications. Hypersensitivity, renal and / or hepatic insufficiency, blood diseases with a tendency to hemorrhage, glucose-6-phosphate dehydrogenase deficiency, pregnancy, lactation.
Caution: Gilbert's syndrome (constitutional hyperbilirubinemia), children under 16 years.
Dosage regimen. Inside, after eating, 1 pack. 3-4 times a day for 3-5 days. 1 pack. dissolve the preparation in ½ Cup of hot water (a slight precipitate in a glass is allowed). Use freshly prepared solution.
Side effect. Allergic skin reactions, nausea, vomiting, headache, drowsiness, General weakness, dizziness. Rarely-thrombocytopenia, leukopenia, agranulocytosis. With long-term use in high doses, hepatotoxic and nephrotoxic action is possible.
Overdose. Symptoms: nausea, vomiting, stomach pain, after 1-2 days — liver failure, encephalopathy, comatose state.
Treatment: induce vomiting, wash the stomach, the appointment of adsorbents (activated carbon), symptomatic therapy (methionine, acetylcysteine).
Interaction. Should be avoided combination of the drug with barbiturates, anticonvulsants, phenytoin, carbamazepine, rifampicin, zidovudine and other inductors of microsomal liver enzymes.
Special instruction. To avoid liver toxicity, do not combine the drug with ethanol. During treatment should refrain from driving vehicles and activities potentially hazardous activities, require high concentration and psychomotor speed reactions.
