Expiration date: 04/2025
Structure and Composition:
Film-coated tablets. 1 tablet contains melatonin 3 mg
Excipients: dibasic calcium phosphate, magnesium stearate, talc MCC pharmaceutical glaze isopropyl alcohol
Description pharmaceutical form:
Round, biconvex film-coated tablets from almost white to bezhevatogo color, with break line on one side of the tablet. View of the fracture: a homogeneous mass of white to almost white.
Characteristic:
The synthetic analogue of the hormone of the pineal gland (epiphysis), derived from the amino acids of vegetable origin.
Pharmachologic effect:
Adjusts the sleep-wake cycle, diurnal variation in locomotor activity and body temperature.
Pharmacokinetics:
When ingestion rapidly and completely adsorbed easily passes gistogematicalkie barriers, including GEB. It has a short T1 / 2.
Description of the pharmacological actions:
It normalizes the circadian rhythms. Speeds up falling asleep, it reduces the number of nighttime awakenings, improves mood after morning awakening (does not cause feelings of lethargy, weakness and fatigue on awakening). It adapts the body for rapid change of time zones, reduces stress reactions. It has immunostimulatory and strong antioxidant properties. It inhibits the secretion of gonadotropins, to a lesser extent - other pituitary hormones (corticotropin, thyrotropin, growth hormone). It does not cause addiction and dependence.
Indications:
Sleep disorders, normalization of biological rhythms.
Contraindications:
Hypersensitivity expressed by the human kidney, leukemia, lymphoma, Hodgkin's disease, myeloma, diabetes mellitus, chronic renal failure.
Application of pregnancy and breastfeeding:
Appointment during pregnancy and lactation - under strict doctor's orders.
Side effect:
When used in physiological doses, adverse reactions are rare. While taking melatonin described allergic reactions, swelling (in the first week of admission), headache, nausea, vomiting, diarrhea, morning drowsiness.
Drug Interactions:
It enhances the effect of drugs which depress the central nervous system, and beta-blockers. It is not recommended to take in conjunction with hormonal drugs is incompatible with MAO inhibitors.
Dosage and administration:
Inside for 30-40 minutes before bedtime. Adults Table 0.5-1. 1 per day. As an adaptogen jet lag - 1 day prior to the flight, and in the next 2-5 days - on 1 tab. in a day. The maximum daily dose - 2 tab. in a day.
Overdose:
Symptoms: Accidental overdose - increased severity of side effects.
Treatment: gastric lavage, symptomatic therapy.
Precautionary measures:
Should not be used during the drivers of vehicles and people skills relate to the high concentration of attention. Contraceptive has a weak effect (it should be borne in mind patients of reproductive age). Avoid bright light.
