Expiration date: 02/2025
Structure and Composition:
1 tablet contains buspirone hydrochloride 10 mg in blister 10 pcs., In box 6 blisters.
Pharmachologic effect:
Selectively blocking presynaptic dopamine receptors and increases the rate of excitation of the midbrain dopamine neurons are selectively turned on (partial agonist) serotonin receptor subtype 1A (5-HT1A).
Pharmacokinetics:
Once inside quickly and completely absorbed from the gastrointestinal tract. Bioavailability - 90%. Plasma protein binding is about 95%. The effect is gradually manifested after 7-14 days, and reaches a maximum - 4 weeks. It is metabolized in the liver by hydroxylation and glyukuronirovaniya to form 1-pirimidinilpiperazina. Report the news mostly in the form of metabolites (1% - unchanged) and through the gastrointestinal tract (18-38%). T1 / 2 precursor - 2.4-2.7 hours, T1 / 2 metabolite -. 4.8 h The drug may penetrate into breast milk.
Description of the pharmacological actions:
Do not have any negative effect on psychomotor functions, it does not cause tolerance, dependence and withdrawal symptoms. It does not potentiate the effect of alcohol.
Testimony:
Generalized anxiety disorder, panic disorder, vegetative dystonia syndrome, alcohol withdrawal syndrome (adjuvant therapy), mild depression (adjuvant therapy).
Contraindications:
Hypersensitivity, severe violations of the kidneys and liver, glaucoma, myasthenia gravis, pregnancy, breast-feeding.
Application of pregnancy and breastfeeding:
Contraindicated during pregnancy. At the time of treatment should stop breastfeeding.
Side effect:
From the nervous system and sensory organs: headache, nervousness, sleep disorders, rarely - extrapyramidal disorders.
From the digestive tract: loss of appetite, nausea, vomiting, diarrhea.
Drug Interactions:
In combination with MAO inhibitors may develop a hypertensive crisis.
Dosage and administration:
Inside. Dosage is determined individually. The recommended starting dose of - 5 mg 3 times a day, if necessary, can be increased by 5 mg every 2-3 days. The average daily dose - 20-30 mg. The maximum single dose - 30 mg daily - 60 mg.
Overdose:
Symptoms: nausea, vomiting and other gastrointestinal disorders, dizziness, cramps, drowsiness..
Treatment: gastric lavage, the appointment of activated charcoal, symptomatic therapy. Dialysis is ineffective.
Precautionary measures:
It should be administered cautiously in conjunction with antipsychotics, antidepressants, cardiac glycosides, antihypertensives, antidiabetic drugs, oral contraceptives. In renal and liver failure mild to moderate severity, cirrhosis of the liver should be administered under close medical supervision, usually in smaller doses.
