Expiration date: 01/2025
Description:
Plasma-tool.
Composition:
100 ml of solution contains Hydroxyethyl starch 6 or 10 g.
Indications for use:
As plasma-treatment for hypovolemia and shock associated with operative interventions, injuries, infectious diseases and burns; disorders of microcirculation; therapeutic hemodilution.
Contraindications:
Gipergidratace, hypervolemia, decompensated heart failure, renal failure with oliguria or anuria, cardiogenic pulmonary edema, intracranial bleeding, severe disorders of blood clotting, increased sensitivity to GEK.
Pharmacodynamics:
Plasma-tool gidroksietilirovanny starch (HES). HES is high molecular compound consisting of polymerized residues of glucose, which is obtained by gidroksietilirovanny amylopectin is a natural polysaccharide contained in the starch of potatoes and corn wax ripeness. Amylopectin is rapidly hydrolyzed in blood, his presence in the bloodstream is about 20 min. To increase the stability and increasing the duration of action of the amylopectin is subjected to gidroksietilirovanny. The depth of this process is characterized by the degree of substitution.
The intensity and duration abhisamaya of action of drugs SEC determined molecular weight and degree of substitution of the substance of the SEC. The higher the degree of substitution, the longer HES in the circulating blood. When the ratio C2/C6 of more than 8 GEK metabolized in the body much more slowly than when the ratio is less than 8.
Pentakrahmal has a molecular weight of about 200,000 daltons and degree of substitution of about 0.5; the ratio C2/C6, the defining features of substitution is equal to 6.
Improves rheological properties of blood by reducing the hematocrit, reduces plasma viscosity, reduces erythrocyte aggregation, contributes to the restoration of disturbed microcirculation.
Deposited in the cells of the RES that has no clinical significance.
Pharmacokinetics:
After the on/in infusion pentakrahmal undergoes extensive metabolism, laminating (serum amylase) to molecular fragments. Products of metabolism with molecular weight less than 50,000 daltons are rapidly cleared by the kidneys. About 70% of the dose excreted in the urine within 24 h and 80% within weeks.
Side effects:
Allergic reactions: possible hives, anaphylactic reactions; rare - hard, but reversible skin itch.
The method of preparation or use:
The mode set individually depending on age, indications, clinical situation. Administered in the form of in/infusion.
Storage conditions:
In a dry place at a temperature of 10-25 °C.
