Expiration date: 02/2026

Structure and Composition:

Film-coated tablets. 1 tablet contains doxilamine succinate 15 mg

Excipients: lactose monohydrate MCC croscarmellose sodium magnesium stearate, hypromellose pigment dispersion Sepispers AR 7001 (composition - hypromellose, titanium dioxide, propylene glycol, purified water), macrogol 6000, purified water

in 30 pieces tubes. in box 1 tube.

Description pharmaceutical form:

Film-coated tablets: rectangular, white, scored on both sides. Color on a break - white.

Pharmacokinetics:

Absorption is high, is metabolized in the liver. It penetrates through the blood-tissue barriers (including GEB). Displayed by 60% by the kidneys unchanged, partly - through the gastrointestinal tract.

Description of the pharmacological actions:

Blocker of H1-histamine receptors from the group ethanolamines. The drug has a hypnotic, sedative and m-anticholinergic action. Reduces sleep time, increases the duration and quality of sleep, it does not change the phase of sleep. Duration of action - 6-8 hours.

Testimony:

• sleep disturbances
  
• insomnia.
  

Contraindications:

• Hypersensitivity to doxylamine or other ingredients
  
• angle-closure glaucoma
  
• prostatic hyperplasia, urinary retention
  
• breastfeeding
  
• childhood and adolescence (15 years).
  

Application of pregnancy and breastfeeding:

The drug should be used with caution during pregnancy. Before use, you should consult with your doctor.

Side effect:

Possible daytime sleepiness, dry mouth, paresis of accommodation, constipation, urinary retention.

Drug Interactions:

At simultaneous reception Donormila with barbiturates, benzodiazepines, clonidine, opioid analgesics, antipsychotics, anxiolytics dampening effect on the central nervous system. It can reduce the emetic response to apomorphine.

When taken with m-anticholinergic agents increases the risk of side effects: dry mouth, urinary retention.

Due to the fact that alcohol increases Donormila sedation, to avoid consumption of alcoholic beverages and medicines containing alcohol.

Dosage and administration:

Inside, 15 minutes before bedtime, with a little water.

The recommended dose - Table 0.5-1. in a day. If the treatment is ineffective, on doctor's advice dose may be increased to 2 tablets. in a day.

Duration of treatment - 2-5 days. If insomnia persists, treatment should be reconsidered.

Overdose:

Symptoms: daytime drowsiness, dilated pupils (mydriasis), redness of the skin (flushing), increased body temperature (hyperthermia), depressed mood, anxiety, impaired motor coordination, trembling (tremor), involuntary movements of the fingers and toes (athetosis), convulsions (epileptic syndrome), coma. When symptoms of poisoning should immediately seek medical advice

Treatment: symptomatic (appointment of Mr. holinomimetikov et al.).

Special instructions:

Effects on ability to work with machinery and transport control. Avoid activities that require rapid mental and motor responses. This product contains 484 mg of sodium per 1 table. That should be taken into account when calculating the daily consumption at a low-salt diet.