Expiration date: 04/2025
The composition and form of issue:
Tablets. 1 tablet contains:
tizanidine (hydrochloride) 2 or 4 mg
excipients: silica colloidal anhydrous stearic acid microcrystalline lactose monohydrate
blistere in 10 PCs. in cardboard pack 3 blisters.
Pharmacological action:
Reduces the release of excitatory amino acids from the intermediate neurons of the spinal cord.
Description pharmacological action:
Has antispastic effect in chronic spastic conditions of the spinal and cerebral origin, eliminates acute painful muscle spasms and clonic convulsions, reduces resistance to passive movements, increases the strength of an arbitrary contractions.
Indications:
Muscle pain accompanied by spasm in various diseases of spine (osteochondrosis, spondylosis, cervical and lumbar syndromes, etc.), surgery (for hernia of the intervertebral disc or hip osteoarthritis), spasticity in neurologic diseases (disseminated sclerosis, chronic myelopathy, degenerative spinal cord disease, traumatic brain injury, cerebrovascular accident, etc.).
Contraindications:
Hypersensitivity, children's age.
Application of pregnancy and breast-feeding:
With caution in pregnancy, breast-feeding should be discontinued.
Side effects:
Nausea, dry mouth, gastrointestinal disorders, dizziness, weakness, drowsiness, slight decrease in blood pressure.
Method of application and dose:
Inside. The dosage regimen should be individualized.
For painful muscle spasm prescribed a drug Sirdalud dose of 2 or 4 mg 3 times a day. In severe cases, before going to sleep you can also take 2 or 4 mg.
When spasticity of skeletal muscles due to neurologic diseases, the dose should be selected individually.
The initial daily dose should not exceed 6 mg divided in 3 doses. The dose can be increased gradually by 2-4 mg at intervals from 3-4 to 7 days. Typically, the optimal therapeutic effect is achieved at a daily dose of from 12 to 24 mg, divided into 3 or 4 doses at intervals of time. Should not exceed 36 mg/day.
Use in patients with renal insufficiency. Treatment of patients with renal insufficiency (Cl creatinine <25 ml/min) it is recommended to start with a dose of 2 mg 1 time per day. The doses are small "steps", taking into account the tolerability and effectiveness. If you want to get a more pronounced effect, it is recommended to increase the dose that is assigned 1 times per day, then increase the multiplicity of destination.
Precautions:
Care should be taken when violation of the kidney and/or liver. It is recommended to avoid all activities that require a high degree of concentration of attention (driving vehicles, work with potentially dangerous machines and mechanisms).
