• Glucose (Dextrose) 40% 10ml 10 vials

Expiration date: 07/2025

International nonproprietary name or grouping name: dextrose.

Dosage form: solution for intravenous injection.

Composition: 

1 ml of solution contains:

active substance: dextrose monohydrate (in terms of dry substance dextrose) 400 mg, 

auxiliary substances: hydrochloric acid (0, 1 M hydrochloric acid), sodium chloride, water for injections.

Description

Transparent slightly colored liquid.

Pharmacotherapeutic group: food carbohydrate means.

Pharmacological properties

Glucose enhances the redox processes in organism, improves antitoxic function of the liver covers a part of the energy expenses of the organism as a source of carbohydrate. Entering the tissues fosfauriliruetsa, turning into glucose-6-phosphate, which is actively involved in many phases of metabolism of the body.

A solution of 400 mg/ml is hypertonic. When administered into a vein hypertonic solution increases the osmotic pressure of the blood, increases the contractile activity of the heart muscle, expands blood vessels, improves the detoxification function of the liver, increases diuresis.

Pharmacokinetics

Fully absorbed by the body, kidney is not displayed (the appearance in the urine is a pathological sign).

Testimony

Hypoglycemia, lack of carbohydrate food, poisoning, intoxication, liver diseases (hepatitis, dystrophy and atrophy of the liver, including liver failure), hemorrhagic diathesis, intoxication, collapse, shock. 

As a component of various blood-substituting and anti-shock fluids, for the preparation of solutions of drugs for intravenous injection. 

Contraindications

Hypersensitivity, hyperglycemia, hyperlactacidemia, gipergidratace, postoperative disorders of glucose utilization, circulatory disorders, threatening swelling of the brain and lungs, cerebral edema, pulmonary edema, acute left ventricular failure, hyperosmolar coma, childhood. 

Be wary decompensated chronic heart failure, chronic renal failure (oligo-, anuria), hyponatremia, diabetes mellitus. 

Method of application and doses

Intravenous drip up to 30 drops/min (1, 5 ml/min), the maximum daily dose for adults – 250 ml.

For a more complete assimilation of dextrose administered in large doses, along with her prescribed insulin at the rate of 1 UNIT of insulin for 4-5 g of dextrose. Patients with diabetes dextrose is administered under the control of its content in the blood and urine.

Side effects 

Disorders of ionic balance, hyperglycemia, glycosuria, fever, hypervolemia, acute left ventricular failure. In the introduction – the development of infection, thrombophlebitis.

Overdose

Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, gipergidratace, violation vodno-elektrolitnogo balance. Treatment: to stop the introduction of glucose to enter insulin, symptomatic therapy. 

Interaction 

When combined with other drugs it is necessary to visually control the work (possible invisible pharmaceutical or pharmacodynamic incompatibility).

Special instructions

Glucose cannot enter the fast or for a long time. If in the process of infusion solution occurs chills, the introduction should cease immediately. To prevent thrombophlebitis, the solution should be administered slowly via a large vein. 

When combined with other drugs it is necessary to visually control the work.

Patients with diabetes mellitus dextrose is administered under the control of its content in the blood and urine.

Release form

The intravenous solution 400 mg/ml.

5 ml, 10 ml ampoules of neutral glass or polymeric ampoules from high-pressure polyethylene or low pressure polyethylene, or polyethylene for medical purposes, or of polyethylene or of polypropylene for infusion solutions and injectable drugs.

10 ampoules of neutral glass with the instructions for use are placed in a box made of cardboard with a corrugated liner of paper burst. 

In each box put a knife ampulnam or scarifier. 

If you package vials with notches, rings and dots knives ampoule or scarifiers do not invest.

10 ampoules polymer with instructions for use is placed in cardboard pack. 

Storage conditions

At a temperature of from 5 to 30 °C.

Keep out of reach of children.

Shelf life

5 years in ampoules of neutral glass, 3 years in ampoules polymer.

Do not use after the expiry date printed on the package.

Glucose
(Dextrose)
40%
10ml
10
vials

  • $5.00