Expiration date: 12/2026
Active substances
Heparin sodium (heparin sodium) Rec.INN registered by WHO
Onion (Onion) BP British Pharmacopoeia
Allantoin (allantoin) USAN accepted for use in the USA
Release form, packaging and composition of the drug Kontraktubex
The gel for external use is matte, from light yellow to light brown in color, with a characteristic odor.
Clinical and pharmacological group: A drug with proteolytic activity that promotes the resorption of keloid scars, for external use
Pharmaco-therapeutic group: Hyperrub treatment
Pharmacological action
A combined medicinal product for external use. It has fibrinolytic, anti-inflammatory (due to onion extract), antithrombotic (due to heparin), and keratolytic effect (due to allantoin). Stimulates cellular regeneration without hyperplasia. Inhibits the proliferation of keloid fibroblasts.
Pharmacokinetics
In experimental studies, it was shown that heparin penetrates the connective tissue of the dermis in a clinically sufficient amount for 4 hours. Deep penetration is provided by a combination of heparin with Serae bulb extract and allantoin (transepidermal heparinization).
Indications of active substances of the drug Contractubex
Hypertrophic and keloid scars that occur after surgical operations, amputations, burns and injuries; ankylosis (contracture) of joints; Dupuytren's contracture; traumatic tendon contractures; stretch marks after pregnancy; atrophic scars (in particular, those that occur after acne or furunculosis); prevention of pathological scar formations in the postoperative period or after injury.
Dosage regimen
The method of application and dosage regimen of a particular drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.
Externally.
It is applied to the scar surface for adults - 2-4 times / day, for children older than 1 year - 1-2 times / day.
Depending on the indications, the course of treatment ranges from 4 weeks to 1 year.
Side effect
From the skin: often - itching, erythema, telangiectasia, scar atrophy; infrequently - skin hyperpigmentation, skin atrophy; frequency is not established - urticaria, rash, erythema, skin irritation, papules, burning sensation, tension, contact dermatitis, peeling at the site of application.
Infectious diseases: the frequency is not established - pustular rashes.
On the part of the immune system: the frequency has not been established - hypersensitivity (allergic reactions).
From the nervous system: the frequency is not established - paresthesia.
Violations at the site of application: the frequency is not established - swelling, pain.
Contraindications to use
Hypersensitivity to the components of the combination; pregnancy, breastfeeding; children under 1 year of age.
Use during pregnancy and lactation
Contraindicated use during pregnancy and during breastfeeding.
Use in children
It is contraindicated in children under the age of 1 year.
Use in elderly patients
There are no indications for limiting the use of elderly patients.
Special instructions
When treating fresh scars, ultraviolet radiation, exposure to cold and intensive massage should be avoided.
