Expiration date: 04/2025
The composition and form of issue:
1 vial with 1 ml solution for injection contains concentrate of marine organisms 10 mg (active agent) and excipients: phenol water for injections in blistere 5 PCs., in box 2 blisters.
Feature:
Extract from marine organisms. Contains mucopolysaccharides, chondroitin sulfate, amino acids, peptides, ions of sodium, potassium, calcium, magnesium, iron, copper and zinc.
Pharmacological action:
Inhibits the activity of hyaluronidase, prevents the destruction of the macromolecular structure of the ground substance of connective tissue and stimulates recovery processes in the interstitial tissue and in the articular cartilage tissue, normalizes the biosynthesis of hyaluronic acid.
Clinical pharmacology:
Reduces pain at rest (more than 90%), when driving and walking on a flat surface (in some cases, when climbing stairs), local swelling, the severity of contractures. Increases motor activity in the affected joint and range of motion. Lowers ESR content seromucoid, fibrinogen, globulins, white blood cell count, C-reactive protein in synovial fluid. 2 times increases the level of hyaluronic acid in synovial fluid (after 6 months of treatment).
Indications:
Degenerative rheumatic diseases (gonarthrosis, coxarthrosis, degenerative disc disease, spondylosis, arthrosis of small joints of hands and feet), traumatic dysostosis, hondaline and endochondral ossification disorders, the most common (adjuvant therapy).
Contraindications:
Pregnancy, lactation, childhood and adolescence.
Application of pregnancy and breast-feeding:
Contraindicated. At the time of treatment should stop breastfeeding.
Side effects:
Transient dermatitis at the injection site, mild myalgia, transient arthralgia increased after intra-articular injection.
Method of application and dose:
In/m deep, and 1 ml daily for 20 days with involvement of large joints — intra-articular 1-2 ml each affected joint 1 every 3-4 days (5-6 injections), then — in/m for 20 days. Recurrence rate after 6 months.
