Expiration date: 11/2026
The dosage form
is a colorless or light yellow to light brownish-yellow liquid.
Composition
Composition per 1 ml:
Bioactive extract from small sea fish - 1.0 ml
includes:
Active substance: concentrated extract from small sea fish - 0.1 g/ml
Excipients: phenol - up to 0.005 g/ml; water for injection up to 1.0 ml
The pharmacotherapeutic group
of tissue repair is a stimulant of natural origin
Pharmacodynamics
Pharmacological properties
AMBENE® is a bio-chondroprotector, the active component of which is a bioactive extract from small marine fish. The extract contains mucopolysaccharides (chondroitin sulfate), amino acids, peptides, ions of sodium, potassium, calcium, magnesium, iron, copper and zinc.
AMBENE® Bio prevents the destruction of macromolecular structures of normal tissues, stimulates the recovery processes in interstitial tissue and articular cartilage tissue, which explains its analgesic effect. The anti-inflammatory effect and tissue regeneration are based on inhibition of hyaluronidase activity and normalization of hyaluronic acid biosynthesis. Both of these effects are synergistic and cause the activation of regenerative processes in tissues (in particular, the restoration of cartilage structure).
Indications
AMBENE® Bio is used in adults with primary and secondary osteoarthritis of various localization (coxarthrosis, gonarthrosis, osteoarthritis of small joints), osteochondrosis and spondylosis.
Contraindications
Hypersensitivity to the components of the drug.
Pregnancy and lactation.
Children's age.
With caution
It is not recommended to prescribe the drug in adolescence due to the lack of scientific clinical data in this category of patients.
Use during pregnancy and lactation
AMBENE® Bio is contraindicated during pregnancy. If it is necessary to use the drug during lactation, breastfeeding should be discontinued.
Method of administration and dosage
For polyosteoarthritis and osteochondrosis, the drug is administered intramuscularly 1 ml per day. The course of treatment is 20 injections (1 injection per day for 20 days).
In case of predominant damage to large joints, the drug is injected intra-articularly 1-2 ml into each joint with an interval of 3-4 days. There are 5-6 injections per course in each joint.
A combination of intra-articular and intramuscular injection is possible.
It is advisable to repeat the course of treatment 6 months after consulting a doctor.
Side effects
The frequency of adverse reactions listed below was determined according to the following gradation: very common (>1/10), common (>1/100, ?1/10), infrequent (>1/1000, ?1/100), rarely (>1/10000, ?1/1000), very rarely (?1/10000).
Allergic reactions: rarely - itching; very rarely - anaphylactic reactions.
Local: rarely - redness of the skin and burning sensation at the injection site.
Other: short-term myalgia. In some cases, intra-articular injections may cause a temporary increase in pain.
Overdose
In case of overdose, allergic reactions (sometimes severe) may occur in predisposed patients.
Drug interaction
To date, they have not been identified.
Special instructions
In case of individual intolerance to seafood (sea fish), the risk of allergic reactions increases.
Effects on the ability to drive vehicles and mechanisms
There is no data on the adverse effects of the drug on the ability to drive vehicles and mechanisms.
Storage temperature
from 15℃ to 25℃
