Expiration date: 07/2026
Active ingredient: gimecromone - 200 mg;
excipients: potato starch - 45.0 mg, gelatin -3.0 mg, sodium lauryl sulfate - 1.0 mg, magnesium stearate - 1.0 mg.
Pharmacological action
Pharmacotherapeutic group:
choleretic agent.
ATX Code:
A05AH02
Pharmacological properties
Pharmacodynamics
A choleretic drug. Increases the formation and excretion of bile. It has a selective antispasmodic effect on the bile ducts and the Oddi sphincter (it does not reduce peristalsis of the gastrointestinal tract and blood pressure). Reduces bile stasis, prevents cholesterol crystallization and thus the development of cholelithiasis.
Pharmacokinetics
When ingested, it is easily absorbed from the digestive tract and weakly binds to plasma proteins. The maximum concentration in the blood serum is reached after 2-3 hours. The half-life is about 1 hour. Himecromone is excreted by the kidneys (about 93% in the form of glucuronate, 1.4% - sulfonate, 0.3% - unchanged).
Indications
Biliary dyskinesia and Oddi sphincter hyperkinetic type, non-calculous chronic cholecystitis, cholangitis, cholelithiasis; condition after surgical interventions on the gallbladder and bile ducts. Decreased appetite, nausea, constipation, vomiting (on the background of hyposecretion of bile).
Use during pregnancy and lactation
There is no data on the safety of using gimecromone during pregnancy and lactation. The use of Gimecromon-SZ during pregnancy and breast-feeding is permissible as prescribed by a doctor only in cases where the potential benefit to the mother exceeds the potential risk to the fetus and child.
Contraindications
Hypersensitivity.
Biliary tract obstruction, renal/hepatic insufficiency, ulcerative colitis, Crohn's disease, peptic ulcer of the stomach and duodenum, hemophilia. Children under 7 years of age.
Side effects
Allergic reactions are possible; diarrhea, flatulence, abdominal pain, ulceration of the gastrointestinal mucosa, headache.
If you experience side effects listed in the instructions or they worsen, or you notice any other side effects not listed in the instructions, tell your doctor.
Interaction
Morphine weakens the effect of hymecromone.
When combined with metoclopramide, the effect of both drugs is weakened.
Enhances the effects of indirect anticoagulants.
How to take it, course of administration and dosage
Inside, 30 minutes before meals; adults - 200-400 mg (1-2 tablets) three times a day.
The daily dose is 1200 mg.
For children from 7 years of age, 200 mg (1 tablet) once or three times a day.
The daily dose is 600 mg.
The course of treatment is 2 weeks.
If you miss a dose, you should take the drug as soon as possible or, if the time of the next dose is approaching, do not take the missed dose. Do not take a double dose at once.
If there is no improvement after treatment, or the symptoms worsen, or new symptoms appear, it is necessary to consult a doctor. Use the drug only according to the indications, the method of use and in the doses specified in the instructions.
Overdose
To date, no cases of overdose have been reported.
Description
Tablets are white or almost white in color, round, flat-cylindrical with a chamfer and a risk on one side.
Special instructions
It does not impair the secretory function of the digestive glands and intestinal absorption processes.
Influence on the ability to drive vehicles, mechanisms
The drug Gimecromon-SZ has no effect on the ability to drive vehicles and engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Form of release
200 mg tablets.
10 tablets each in a contour cell package made of PVC film and aluminum foil.
30 tablets each in polymer cans of BP type made of low-pressure polyethylene with caps made of high-pressure polyethylene or in polymer vials made of low-pressure polyethylene with caps made of high-pressure polyethylene.
Each jar, bottle, 2, 3, 4, 5, 9 The cell contour packages, together with the instructions for use, are placed in a cardboard pack.
Storage conditions
In a place protected from light, at a temperature not exceeding 25 ° C.
Keep out of reach of children.
Expiration date
3 years.
Do not use after the expiration date.
Active substance
Hymecromone
Dosage form
of the tablet
