Expiration date: 07/2026
Dosage form
Round, flat-cylindrical tablets from almost white to white in color with a chamfer on the edges on both sides and a risk on one side.
Composition
Active ingredient: gimecromone - 200 mg:
Excipients: corn starch - 45.00 mg, gelatin - 3.00 mg, sodium lauryl sulfate - 1.00 mg, magnesium stearate - 1.00 mg.
Description
When ingested, it is easily absorbed from the digestive tract and weakly binds to plasma proteins. The maximum concentration in the blood serum is reached after 2-3 hours. The half-life is about 1 hour. Himecromone is excreted by the kidneys (about 93% in the form of glucuronate, 1.4% - sulfonate, 0.3% - unchanged).
Pharmacotherapeutic group
choleretic agent
Pharmacodynamics
A choleretic drug. Increases the formation and excretion of bile. It has a selective antispasmodic effect on the bile ducts and the Oddi sphincter (it does not reduce peristalsis of the gastrointestinal tract and blood pressure). Reduces bile stasis, prevents cholesterol crystallization and thus the development of cholelithiasis.
Indications
Hyperkinetic dyskinesia of the biliary tract and Odddy's sphincter, non-calculous chronic cholecystitis, cholangitis, cholelithiasis; condition after surgical interventions on the gallbladder and bile ducts. Decreased appetite, nausea, constipation, vomiting (on the background of hyposecretion of bile).
Contraindications
Hypersensitivity.
Biliary tract obstruction, renal/hepatic insufficiency, ulcerative colitis, Crohn's disease, peptic ulcer of the stomach and duodenum, hemophilia.
Children under 7 years of age.
With caution:
There is no data on the safety of using gimecromone during pregnancy and lactation.
The use of Gimecromon during pregnancy and lactation is permissible as prescribed by a doctor only in cases where the potential benefit to the mother exceeds the potential risk to the fetus and child.
Method of administration and dosage
Inside, 30 minutes before meals. Adults take 200-400 mg (1-2 tablets) three times a day. The daily dose is 1200 mg.
For children from 7 years of age, 200 mg (1 tablet) once or three times a day.
The daily dose is 600 mg.
The course of treatment is 2 weeks.
If you miss a dose, you should take the drug as soon as possible or, if the time of the next dose is approaching, do not take the missed dose. Do not take double doses at once.
If there is no improvement after treatment, or the symptoms worsen, or new symptoms appear, it is necessary to consult a doctor. Use the drug only according to the indications, the method of use and in the doses specified in the instructions.
Side effects
Allergic reactions, diarrhea, flatulence, abdominal pain, ulceration of the gastrointestinal mucosa, headache are possible.
If you experience side effects listed in the instructions or they worsen, or you notice any other side effects not listed in the instructions, tell your doctor.
Overdose
To date, no cases of overdose have been reported.
Drug interaction
Morphine weakens the effect of hymecromone. When combined with metoclopramide, the effect of both drugs is weakened. Enhances the effects of indirect coagulants.
Special instructions
It does not impair the secretory function of the digestive glands and intestinal absorption processes.
Effects on the ability to drive vehicles and other mechanisms:
The drug has no effect on the ability to drive vehicles and engage in potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.
Storage temperature
from 2℃ to 25℃
