Expiration date: 09/2025
The composition and form of issue:
Tablets. 1 tablet contains:
allopurinol 100 mg
excipients: sucrose (sugar refined) starch magnesium stearate (magnesium stearinovokisly) food gelatin
in a contour acheikova packing 10 PCs. in cardboard pack 5 packs or in the banks dark glass or polymer banks to 50 PC. in the paper cartons 1 Bank.
Method of application and dose:
Inside, after eating, drinking plenty of water. Daily urine volume should be greater than 2 l, and the urine reaction — neutral or slightly alkaline. Daily dose of over 300 mg should be divided into several intakes.
Adult use of the drug in the lung disease is in a daily dose of 100-200 mg/day in diseases of moderate, 300-600 mg/day in heavy over — 700-900 mg/day. The dose is selected individually, the effectiveness of therapy is monitored in the initial stages by re-determining the level of uric acid in the blood (desirable level <0, 36 mmol/l). Reducing the level of uric acid under the influence of the drug occurs 24-48 hours.
To reduce the risk of acute gout treatment starts with a dose of 100-300 mg/day, with weekly and, if necessary, increase the dose by 100 mg/day.
To prevent urate nephropathy during chemotherapy allopurinol administered in a daily dose of 600-800 mg, and continue treatment for 2-3 days.
With recurrent calcium oxalate kidney stones in patients with hyperuricosuria dose — 200-300 mg/day.
Children from 10 to 15 years is prescribed 10-20 mg/kg/day or 100-400 mg / day to 10 years 5 to 10 mg/kg/day.
Patients with violation excretory function of kidneys a daily dose of allopurinol should be reduced. The first 6-8 weeks of treatment need regular liver function tests, blood diseases that require regular laboratory control.
In chronic renal failure need to start with a daily dose not exceeding 100 mg/day with an interval of more than 1 day, only increasing it when insufficient therapeutic effect. When added to the uricosuric drugs, the dose of allopurinol gradually increased, and effect of funds — reduced. During treatment it is necessary to ensure a daily urine output of not less than 2 years, to maintain the urine pH to neutral or slightly alkaline level.
When Cl creatinine >20 ml/min assigned to usual doses of allopurinol when CL creatinine <10-20 ml/min daily dose should not exceed 200 mg.
