Expiration date: 04/2025

Structure and Composition: 

Film-coated tablets, soluble in the gut . 1 tablet contains S-adenosylmethionine 400 mg

(In terms of ion ademethionine)

Excipients: polyplasdone X E-10 (crospovidone) MCC magnesium stearate, mannitol

shell: hydroxypropyl akriliz plasdon ES-630 polyethylene glycol 6000

Description pharmaceutical form:

Tablets, coated yellow, oblong (The Oblongs). The cross section shows two layers.

Description of the pharmacological actions:

Heptor refers to hepatic group, has antidepressant activity, detoxifying, regenerating, antioxidant, and neuroprotective antifibroziruyuschim.

Ademethionine included in the biochemical processes of the body while stimulating the production of endogenous ademetionina. Ademethionine (S-adenosyl-L-methionine) - biological substance which is found in all tissues and body fluids. Its molecule incorporated into most biological responses, and as a donator of methyl groups - methylation of the phospholipids in the composition of the lipid cellular membrane layer (transmethylation), and as a precursor of physiological thiol compounds - cysteine, taurine, glutathione, one of the most important intracellular toxicity control agents, CoA and others. (transsulfatirovanie), and as a precursor of polyamines - putrescine, stimulating cell regeneration and proliferation of hepatocytes, spermidine, spermine, included in the structure of ribosomes (aminopropilirovanie).

Testimony:

• intrahepatic cholestasis
  
• hepatitis of various genesis: toxic (including alcohol), viral medicines (antibiotics, anti-cancer, anti-tuberculosis and anti-viral drugs, tricyclic antidepressants, oral contraceptives)
  
• pretsirroticheskie state
  
• cirrhosis of the liver
  
• encephalopathy secondary genesis
  
• depressive syndromes, including secondary
  
• alcohol withdrawal syndrome.
  

Contraindications:

Hypersensitivity.

Application of pregnancy and breastfeeding:

It is not recommended to take in I-II trimester of pregnancy and during breastfeeding.

Side effect:

Due to the fact that the active drug substance has an acidic pH, some patients may experience discomfort in the epigastrium when using tablets. In any case, these feelings are short-term, are not marked and should not be a reason for discontinuation of treatment.

Drug Interactions:

Interactions with other drugs have not been observed.

Dosage and administration:

Inside, swallowing whole, without chewing. To enhance therapeutic effect is recommended to take the tablets between meals. During maintenance therapy, the recommended daily dose - 800-1600 mg (2-4 table.). The duration of maintenance therapy - an average of 2-4 weeks.

Overdose:

Clinical cases of overdose were reported.

Special instructions:

Given the invigorating effect of the drug is not recommended to be taken before bedtime. Oral administration of the drug to patients with liver cirrhosis associated with hyperasotemia, should be under the supervision of a physician with the nitrogen level control. Heptor tablet formulation must be removed from the packaging immediately before the reception. Tablets are specially coated drug, which dissolves only in the intestine, thereby ademetionine is released in the duodenum.