Expiration date: 08/2025
Active ingredient: milk Thistle spotted fruit (Cardui mariae fructus)
DAB Pharmacopoeia of Germany
Dosage form
The drug is allowed to be used as a means of over the counter release Carsil ® Max
Capsules
reg. Number: PL-005250 from 20.12.18 - Current
Product form, packaging and composition of Carsil ® Max
Capsules are solid gelatinous, cylindrical, size #0; the body is pink-brown, the lid is brown; the contents of the capsules are a powdery mass from light yellow to yellow-brown with agglomerates, with a weak characteristic smell.
1 capsule:
dry extract of milk Thistle fruit 200-275 mg,
which is equivalent to the silymarin content of 110 mg
Excipients: mannitol from 125 to 50 mg, povidone K25-9.4 mg, Polysorbate 80-3.7 mg, sodium lauryl sulfate-3.7 mg, sodium carboxymethyl starch (type A) - 14.8 mg, magnesium stearate - 3.7 mg, silicon dioxide colloidal anhydrous - 3.7 mg, sodium bicarbonate-6 mg.
Composition of the capsule shell: body - red iron oxide dye (E 172) - 0.5286%, yellow iron oxide dye (E 172) - 0.3857%, titanium dioxide (E 171) - 2%, gelatin - up to 100%; cap - black iron oxide dye (E 172) - 0.2857%, red iron oxide dye (E 172) - 0.1619%, titanium dioxide (E 172) - 0.6666%, gelatin - up to 100%.
6 PCs. - PVC/aluminum foil blisters (5) - cardboard bundles.
Clinical and pharmacological group: Hepatoprotector
Pharmaco-therapeutic group: Hepatoprotective agent
Pharmacological action
Means of plant origin. The main thing is the hepatoprotective effect. Flavolignany, including silybin, dehydrosilybin, isosilybin, silymarin, and dehydrosilybin, silychristin, Taxifolin (2.8-3.8%) stabilize lysosomal and cell membranes, preventing release of cell enzymes. They interact with free radicals and inhibit the processes of lipid peroxidation. Due to its antioxidant action, it inhibits the penetration of various toxins into the liver cells (including chlorinated hydrocarbons, alpha-amanitin of the pale grebe, nitrozoamines). Silybin, silymarin and their derivatives stimulate specific RNA polymerase A, which activates the synthesis of proteins and phospholipids in hepatocytes, accelerates the processes of regeneration and detoxification in the liver.
Tocopherols, macro- (potassium, magnesium) and trace elements (copper, selenium) contained in fruits contribute to the normalization of metabolic processes. The fatty oil of fruits (20-34%) contains a large amount of unsaturated fatty acids (including linoleic - 50-62%), which have redox properties, contribute to the oxidation of cholesterol and, together with beta-sitosterol, prevent atherosclerosis. Mucus polysaccharides (5%) have an enveloping and gastroprotective effect. The nitrogen-containing compound betaine improves the process of digestion, bile formation in the liver. Milk Thistle fruits have a lactogenic effect.
Indications of active substances of Carsil ® Max
Condition after hepatitis of viral and toxic etiology, liver injuries, operations on abdominal organs; chronic hepatitis, hepatocholecystitis, biliary dyskinesia, pancreatitis, liver cirrhosis; toxic liver lesions (including those caused by the use of aminoglycosides, tetracycline, immunosuppressants, NSAIDs, anti-tuberculosis drugs, barbiturates, tranquilizers; organic solvents; mushroom poisoning, salts of heavy metals metals, halogenated hydrocarbons; alcohol intoxication); hyperlipidemia, prevention of atherosclerosis.
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Dosage regimen
The method of application and dosage regimen of a particular drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.
Take inside. The dose, frequency and duration of use depend on the indications, the age of the patient and the dosage form used.
Side effect
Rarely: a relaxing effect.
Contraindications to use
Hypersensitivity to milk Thistle.
Special instruction
There is a message about the antagonistic interaction of silymarin with yohimbine and phentolamine.
