Expiration date: 12/2025
Composition
1 coated tablet contains active substance 20 mg of trimetazidine dihydrochloride
Packaging: 30 or 60 pcs.
Pharmachologic effect
Trimetazidine Antihypoxanth means. It has antianginal, anti-hypoxic action. Directly affecting cardiomyocytes and neurons in the brain, improves their metabolism and function. Cytoprotective effect it is due to an increase in energy potential, activation of oxidative-decarboxy-regulation and rationalization of consumption of oxygen (increased aerobic glycolysis and fatty acid oxidation blockade). It supports myocardial contractility, prevents a decrease in intracellular ATP and phos-fokreatinina. The conditions of acidosis normalizes the functioning of membrane ion channels, prevents the accumulation of calcium and sodium in kardiomio-tsitah. normalizes the intracellular concentration of potassium ions. Reduces intracellular acidosis and phosphate, caused by myocardial ischemia and reperfusion. It prevents the damaging action of free radicals, preserves the integrity of cellular membranes, prevents activation of neutrophils in the ischemic area, increases the electric potential decreases the yield of the cells and creatine severity of ischemic myocardial injury.
When reducing the frequency of attacks of angina (nitrates reduced consumption), after 2 weeks of treatment, increases exercise capacity, reduced blood pressure drops. Improves hearing and vestibular trial results in patients decreases dizziness and tinnitus.
In vascular pathology eyes restores functional activity of the retina eyes.
Testimony
Ischemic heart disease: prevention of angina attacks (in the complex therapy):
Chorioretinal vascular disorders
Vertigo of vascular origin
Cochle-vestibular disorders ischemic nature (tinnitus, hearing impairment).
Contraindications
Hypersensitivity to any component of the drug,
Renal impairment (creatinine clearance less than 15 mL / min)
Severe hepatic dysfunction,
Pregnancy,
The period of breast-feeding:
Age 18 years (effectiveness and safety have been established).
Dosing and Administration
Inside, during a meal.
The recommended dose regimen of 2-3 tablets (40-60 mg) per day, in 2-3 doses. The course of treatment recommended by the doctor.
Side effects
Allergic reactions (itchy skin).
Rarely from the gastrointestinal tract: gastralgia. nausea, vomiting, headache, feeling of palpitations.
Special instructions
Against the background of treatment in patients with coronary heart disease is a significant decrease in daily requirement of nitrates.
Use of the drug has no effect on the ability to control the car and the performance of work requiring a high rate of mental and physical reactions.
Storage conditions
In a dry, dark place at a temperature no higher than 25 ° C. Keep out of the reach of children.
