Expiration date: 08/2025
The composition and form of issue
Tablets modified-release film coated
1 tablet contains active substance of Trimetazidine dihydrochloride 35 mg.
in the package 30 PCs.
Pharmacological action
Triducard it has antianginal, antihypoxic effects. Directly affecting cardiomyocytes and neurons in the brain, optimizing their metabolism and function. Cytoprotective effect due to higher energy potential, activated oxidative decarboxylation and the rationalization of oxygen consumption (increased aerobic glikoliza and blockade oxidation of fatty acids). Supports myocardial contractility, prevents a decrease in intracellular ATP content and fosfokreatinina. In conditions of acidosis, normalize the functioning of ion channels, prevents accumulation of calcium and sodium in cardiomyocytes, normalizes the intracellular content of potassium ions. Reduces endocellular acidosis and the phosphate concentration caused by myocardial ischemia and reperfusion. Prevents the damaging action of free radicals, preserves the integrity of cell membranes, prevents the activation of neutrophils in the zone of ischemia, increases the duration of the electric potential, reduces the release of creatine kinase from the cells and the severity of ischemic myocardial damage.
When strokes reduces the frequency of attacks (reduced consumption of nitrate), through 2 week of treatment increases tolerance to physical activity, reduced variations in blood pressure. Improves hearing and results of vestibular tests in patients, reduces dizziness and tinnitus.
When vascular pathology eye restores functional activity retina.
Testimony
- Coronary heart disease:prevention of angina (in combination therapy),
- Chorioretinal vascular disorders,
- Dizziness of vascular origin,
- Cochleo-vestibular disorders ischemic nature (tinnitus, hearing loss)
Contraindications
- Hypersensitivity to any component of the drug,
- Renal insufficiency (creatinine clearance below 15 ml/min),
- Expressed violations of the liver,
- Pregnancy,
- Breastfeeding,
- The age 18 years (effectiveness and safety have not been established).
Method of application and doses
Inside, during a meal. The recommended dosing regimen of 2 tablets (70 mg) per day, in 2 doses. The course of treatment for the advice of a doctor.
Side effects
Allergic reactions (itching). Rarely from the gastrointestinal tract: gastralgia, nausea, vomiting, headache, sensation of palpitations.
Special instructions
The drug is not intended for the relief of angina!
In the case of angina should be reviewed and tailor the treatment (medical therapy or revascularization holding).
The use of the drug does not affect the ability to drive a car and perform work requiring high speed mental and physical reactions.
Storage conditions
In a dry, protected from light place, at temperature not exceeding 25 C.
Shelf life - 3 years.
