Expiration date: 01/2025
The composition and form of issue:
1 tablet coated liner contains fenspiride hydrochloride 80 mg. excipients: calcium phosphate disodium, hypromellose, povidone, colloidal anhydrous silica, magnesium stearate, titanium dioxide, glycerol, macrogol 6000 blistere in 15 PCs., in box 2 blisters.
1 ml syrup 2 mg of fenspiride hydrochloride. Excipients: honey flavor (honey, rum, ALCOHOLATES and alcoholic extracts of honey, flowers roses and orange), licorice root extract (a concentrated tincture of licorice root, glucose syrup, anise oil) and vanillic extract (water-alcohol decoction of the pods of vanilla, glycerin, colorant sunset yellow S, methyl parahydroxybenzoate, parahydroxybenzoate, saccharin, sucrose, potassium sorbate, distilled water) in a bottle of 150 ml, box 1 vial.
Pharmacological action:
Fenspiride has antirejection and anti-inflammatory properties, due to the following mechanism of action:
— being the antagonist of H1-histamine receptors, has a vasodilator such as papaverine, the antispasmodic effect
— anti-inflammatory effect is due to decreased production of various inflammatory factors (cytokines, tumor necrosis factor alpha, metabolites of arachidonic acid and free radicals), some of which also have bronchospasm action. However, these effects are observed only at very high doses.
Pharmacokinetics:
Absorbed in the digestive tract relatively slowly. Cmax after ingestion is in the range of from 0.5 to 8 hours (tablets) or 6 hours (syrup). T1/2 is 12 h. report mostly in the urine.
Indications:
Rinofaringitis, laryngitis
— otitis, sinusitis
— rinotraheobronhit
— bronchitis
— bronchial asthma (maintenance therapy)
respiratory effects in measles, pertussis and influenza (syrup).
Contraindications:
Hypersensitivity to the active substance and/or any component of the drug. Tablets are not recommended for use in children, because it developed the drug in the form of syrup.
Application of pregnancy and breast-feeding:
Not recommended during pregnancy, although the occurrence of pregnancy during treatment is not a reason for her interruption. A nursing mother needs at the time of receiving Erespala to abandon breastfeeding.
Side effects:
Diarrhoeal disorders (nausea, stomach pain), drowsiness, urticaria (syrup).
Method of application and dose:
Inside. Adults: before eating, 3-6 tablespoons of syrup (45-90 ml) daily or 1 tab. 2-3 times a day.
Children: 4 mg/kg/day under 2 years (body weight up to 10 kg) — 2-4 teaspoon of syrup (10-20 ml), during meals (can be added to the bottle to drink) after 2 years (body weight more than 10 kg) — 2-4 tablespoons syrup (30-60 ml) daily, before meals.
Overdose:
Symptoms: drowsiness or agitation, nausea, vomiting, sinus tachycardia.
Treatment: gastric lavage, ECG monitoring.
Special instructions:
The preparation contains a dye, sunset yellow S, whereby the reception Erespala can provoke the development of allergic reactions, including asthma attacks, especially in individuals with hypersensitivity to aspirin.
