Expiration date: 01/2026

Pharmachologic effect:

Orungal - antifungal azoles group of synthetic origin. Its effect is to inhibit the key enzyme CYP 450. As a result, stops the formation of the main structural component of the fungal cell wall (ergosterol).

Itraconazole (Orungal current component) is active against yeast, dermatophytes, molds and yeasts. The drug is fungistatic and fungicidal effect.

Indications for use:

Orungal used for fungal infections of various localization, which provoked sensitive fungal microflora. Use it when:

• Onychomycosis;
  
• Ringworm;
  
• Keratitis;
  
• Aspergillosis;
  
• Cryptococcosis;
  
• Candidiasis;
  
• Sporotrichosis;
  
• Trihofitii;
  
• Microsporia;
  
• Athlete;
  
• Mycosis of the eye;
  
• Tropical mycoses;
  
• Deep organ mycoses;
  
• Pityriasis versicolor;
  
• Blastomycosis;
  
• Histoplasmosis;
  
• Paracoccidioidomycosis.
  

Specific indications for oral solution:

• Esophageal candidiasis with immunodeficiency, HIV;
  
• The prevention of fungal infections in the period after bone marrow transplantation in cancer patients with hematologic.
  

Mode of application:

Capsule Orungal not opened, do not chew. Eat whole capsule should only be washed down with water after a meal. When immunodeficiency, neutropenia, AIDS may increase in the post-transplant period, the dosage (because of possible violations of the bioavailability). The doctor takes the decision to change treatment regimens, depending on the effectiveness of the reception Orungal.

Side effects:

Adverse effects on Orungal capsule following:

• Anorexia;
  
• Hepatitis;
  
• Increase of transaminase activity of the liver;
  
• Epigastric pain;
  
• Indigestion;
  
• Toxic liver damage (sometimes lethal);
  
• headache;
  
• Peripheral neuropathy;
  
• dizziness;
  
• Anaphylaxis;
  
• Angioedema;
  
• Itching;
  
• Urticaria;
  
• Stevens-Johnson syndrome;
  
• Rash;
  
• Alopecia;
  
• Swelling in the background of congestive heart failure;
  
• Photosensitivity;
  
• pulmonary edema;
  
• Hypokalemia;
  
• Amenorrhea;
  
• Dysmenorrhea.
  

Contraindications:

Orungal not prescribed for allergies to azoles, lactation, hypersensitivity to the components of the capsules, with care - children, the elderly, women of childbearing age, liver cirrhosis, heart failure, kidney failure. Contraindicated appoint Orungal patients receiving astemizole, digoxin, Levo, cyclosporine, lovastatin, terfenadine, mizolastine, cisapride, quinidine, pimozide, dofetilide, sertindole.

Pregnancy:

Assign Orungal pregnancy in extreme cases in systemic mycoses that endanger patient lives.

Interaction with other drugs:

Absorption of itraconazole impair the histamine receptor antagonists, didanosine, rifampicin, phenytoin, rifabutin, inducers of microsomal oxidation, antacids. The drug prolongs the effect of calcium antagonists, vincristine, digoxin, prednisone, midazolam, terbinafine, triazolam, quinidine, cisapride, vitamin K antagonists, antithrombotic agents. Orungal reduces the effect of warfarin. Carbamazepine reduces the effect of the drug. When taken with lovastatin may develop myopathy. Increases the bioavailability of Orungal indinavir, ritonavir, erythromycin, clarithromycin. When taken with astemizole possible death.

Overdose:

Cases of excess doses are not described. Antidote not. Theoretically, overdose Orungalom necessary to wash out the stomach, appoint adsorbents. Hemodialysis is not effective.

Product form:

Orungal available in capsules (100 mg) oral solution (10 mg / ml). Filling Machine:

• 4 of the capsule;
  
• 14 capsules;
  
• 15 capsules;
  
• 28 capsules;
  
• 42 capsules;
  
• 60 capsules;
  
• 84 capsules;
  
• Bottle of 150 ml (plus capful).
  

Storage conditions:

Storage temperature Orungal solution - up to 25 capsules - 15-30 degrees Celsius. After opening the bottle with the oral solution is not to keep more than a month. Shelf life capsules Orungal - 3 years, the oral solution - 2 years.

Synonyms:

Irunine, trioxane, Itrazol, Rumikoz, Itraconazole, Itrakon, Mikonihol, Teknazol, Sporogal, Orungamin, Orun, Itraconazole-ratiopharm, Sporanox, MFI, Itrasin, Itrungar, Orunzol, Funit, Eszol.

Composition:

Orungal 1 capsule contains 0.1 g of itraconazole Auxiliary components: gelatin, hypromellose, sucrose, macrogol, titanium dioxide, indigo carmine, azorubin.

Orungal 1 ml solution contains 10 mg itraconazole. Auxiliary ingredients: hydroxypropyl-beta-tsiklodekstin, sorbitol, 1,2-propylene glycol, hydrochloric acid, cherry vanilla flavor, sodium gidrohdorid, water prepared.

Active substance: itraconazole

Additionally:

In all diseases of the heart, liver, lungs, kidneys should weigh the risk / benefit ratio of the reception Orungal.

If signs of myocardial insufficiency, peripheral neuropathy drug overturned.

The interval between administration of Orungal and antacids should be more than 2 hours.

Attention!

Description "Orungal" drug on this page is a simplified and enlarged version of the official instructions for use. Before purchasing or using the product, you should consult your doctor and see the summary approved by the manufacturer.

preparation of information being provided is for informational purposes and should not be used as a guide to self-healing. Only a doctor can decide on the appointment of the drug, and to determine the doses and methods of application. - See more at: