Expiration date: 01/2025

Pharmacological action

A drug of biological origin with antimicrobial and antidiarrheal action. Medicinal yeast has an antimicrobial effect due to an antagonistic effect against pathogenic and conditionally pathogenic microorganisms: Clostridium difficile, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Candida kruesei, Candida albicans, Candida pseudotropicalis (in vitro also against Salmonella typhi, Escherichia coli, Shigella dysenteriae, Yersinia enterocolitica). It inhibits the growth of these microorganisms, as well as Enthamoeba hystolitica, Lambliae. Increases local immune defense due to increased production of IgA and other immunoglobulins.

It has an antitoxic effect, especially against Clostridium difficile toxins that cause pseudomembranous colitis, as well as enterotoxins. The mechanism of antitoxic action is associated with the production of a neutralizing factor that acts on intestinal cells through a receptor connected to G protein, as well as with adhesion to enterocytes and a decrease in the activation of adenylate cyclase by enterotoxins and, consequently, a decrease in the secretion of water and salts.

Increases the activity of small intestine disaccharidases (lactase, sucrose, maltase). It has a trophic effect on the mucous membrane of the small intestine due to the polyamines spermin and spermidin.

Pharmacokinetics

Studies of the pharmacokinetics of Enterol have not been conducted.

Indications

• treatment and prevention of dysbiosis
• treatment and prevention of colitis and diarrhea caused by taking antibiotics
• treatment of acute infectious diarrhea in children and adults
• prevention of diarrhea with prolonged enteral nutrition through a probe,
• treatment of irritable bowel syndrome,
• treatment of recurrent diseases caused by Clostridium difficile.

Dosage regimen

Assign adults and children over 3 years of age 1-2 caps. or sachets 1-2 times / day for 7-10 days. Children aged from 1 year to 3 years, the drug is prescribed 1 capsule. 1-2 times/day for 5 days.

Capsules should be washed down with a small amount of liquid. The contents of 1 sachet are diluted in 1/2 cup of warm water.

Side effect

From the digestive system: rarely-dyspepsia (usually not requiring withdrawal of the drug).

Contraindications

When using the drug, the indications in the recommended doses are not established.

Pregnancy and lactation

Adequate and strictly controlled studies of the use of Enterol during pregnancy and lactation have not been conducted.

Special instructions

During the treatment with Enterol, it is not recommended to conduct simultaneous therapy with antifungal drugs.

It is not recommended to drink and dilute the drug with hot water and alcoholic beverages.

Overdose

Currently, cases of overdose of the drug Enterol are not described.

Drug interaction

When Enterol and antifungal drugs are used simultaneously for oral administration, the clinical effectiveness of Enterol decreases.

Storage conditions and terms

The drug should be stored at a temperature not exceeding 25°C, do not freeze. Shelf life - 3 years.