Expiration date: 08/2026
Orgametril
International name: Linestrenol (Lynestrenol)
Group affiliation: progestogen
Description of the active substance (INN): Linestrenol
Dosage Form: pills
Pharmachologic effect:
The synthetic progestogen. It forms a complex with specific cytoplasmic receptors which binds to the chromatin of the target cells and modifying synthetic processes in the cell. It has expressed gestagenic effect on the endometrium: causes uterine mucosa transition from proliferative phase to secretory phase, increases the viscosity of cervical mucus and prevents the implantation of the ovum. It suppresses ovulation, corpus luteum formation and allows to delay the onset of menstruation provided daily administration. With prolonged use as an oral contraceptive drug reduces the risk of inflammatory diseases of the pelvic organs, iron deficiency anemia, it reduces the likelihood of the development of fibrocystic breast, ovarian and endometrial tumors, including endometrial cancer. Protective effect of contraception depends on the duration and lasts for 5 years after the deadline (nulliparous women - not less than 10 years).
Testimony:
For the 5 mg tablets - dysfunctional metrorrhagia (polimenoreya, menorrhagia, metrorrhagia, dysmenorrhea), endometriosis, amenorrhea (primary or secondary), oligomenorrhea, breast, endometrial carcinoma, premenstrual syndrome, suppression of ovulation, the normal delay of menstruation. For tablets 0.5 mg - contraception.
Contraindications:
Hypersensitivity, liver disease, jaundice (including cholestatic, during pregnancy, against steroids), inborn errors of metabolism of cholesterol, diabetes mellitus type 1, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), metrorrhagia (unknown etiology ), itching, porphyria, otosclerosis, pregnancy, ectopic pregnancy (in history) .C caution. Heart failure, hypertension, depression, thromboembolism (history).
Side effects:
From the digestive system: nausea, diarrhea, rarely - increased activity of "liver" enzymes, jaundice. From the nervous system: headache, dizziness, rare - anxiety, depression. With the genitourinary system: bleeding "breakthrough", "smearing" from the genital tract, increased or decreased libido. For the skin: rarely - "vulgar" acne, hirsutism, chloasma, rash, pruritus. Laboratory indicators: reduction of glucose tolerance, hyperlipoproteinemia, hypercoagulation. Other: weight gain, rarely - increased sweating, painful tension of the mammary glands, edema.
Overdose:
Symptoms: nausea, vomiting. Treatment: symptomatic.
Dosage and administration:
Inside. When polimenorea, premenstrual syndrome - 5 mg / day to 14 to 25 day cycle. When Meno and metrorrhagia - 10 mg per day for 10 days during the 3 subsequent treatment cycles are repeated (5 mg / day to 14 to 25 day cycle). In endometriosis - 5-10 mg / day, the minimum rate - 6 months. In cases amenorrhea or oligomenorrhea are treated with estrogen destination (for example ethinyl 0.02-0.05 mg per day for 25 days) and from 14 to 25 day cycle attached lynestrenol 5 mg / day. During cycle 2, treatment is initiated with 5 days menstrualnopodobnoe reaction estrogenic preparation - from 5 to 25 days, and lynestrenol - from 14 to 25 day cycle of 5 mg. This treatment should be repeated for at least 1 more time. When mastitis - a daily dose of 5-10 mg of 10 to 25 day cycle. In the case of premenstrual syndrome - 5 mg / day with 14 to 25 day cycle. In endometrial carcinoma - 30-50 mg / day. To suppress ovulation ovulatory pain in dysmenorrhoea are treated with one cycle of the day, prescribed 5 mg / day every day for several months. If there is a so-called bleeding "breakthrough", the dose should be increased to 10-15 mg / day for 3-5 days. Treatment should be started 2 weeks before the expected menstrual period at a dose of 5 mg / day (at the beginning of treatment in less than 1 week prior to menstruation - 10-15 mg / day) In order to delay the normal menstruation. For the prevention of endometrial hyperplasia in the pre- and post-menopausal: in conjunction with the ever taken minimally effective doses of estrogen - by 2.5-5 mg linestrola for 12-15 days each month. Contraception - 0.5 mg / day 1 to day 28 day cycle at the same time.
Special instructions:
With long-term treatment is indicated for systematic medical examinations, control of lipid and carbohydrate metabolism, the concentration of bilirubin, transaminases, coagulation system. It is recommended to limit intake of fats, carbohydrates (which is especially important for women with initially elevated body weight). With the trend towards hypertension should be controlled blood pressure (to reduce fluid intake to 1.5-2 l / day), diabetes - blood sugar profile (you may need to increase the dose of insulin). In the case of dysfunctional uterine bleeding in women reproduktivnovnogo age is recommended to start treatment after treatment and diagnostic curettage of the uterus. Treatment failure (recurrence of bleeding and endometrial hyperplasia) requires clarification bleeding causes. At long delay menstruation during treatment of ectopic pregnancy should be excluded. Women are predisposed to the appearance of age spots, while taking the drug should avoid exposure to the sun. Contraceptive reliability may be reduced in the case of missing reception 1-2 tablets for diarrhea and / or vomiting, occurred in the first 4 hours after ingestion.
Interaction:
It improves the effectiveness of beta-blockers, cyclosporine, decreases - insulin. The efficiency decreases, while the appointment of barbiturates, phenytoin, rifampin, activated charcoal, laxative drugs. Macrolides increase the risk of liver toxicity.
