Expiration date: 07/2025
hydroxycarbamide Medak
Packaging: 100 capsules
Pharmachologic effect
Hydroxycarbamide Medak - antineoplastic, cytostatic.
Testimony
Chronic myeloid leukemia, osteomyelofibrosis, erythremia, melanoma, brain tumor, head (except for lip) and neck when it is impossible radical surgery or radiation therapy, cervical cancer (for increasing the effectiveness of radiation therapy).
Contraindications
Hypersensitivity, acute renal or hepatic failure, thrombocytopenia (less 100?109 / l), expressed as leukopenia (less 2,5?109 / l), deep anemia virus (varicella zoster) and other infections.
Pregnancy and breast-feeding
Contraindicated during pregnancy. At the time of treatment should stop breastfeeding.
Dosing and Administration
Inside, if necessary (the impossibility of swallowing capsules) capsule contents are poured into a glass of water and taken immediately. Used as monotherapy (palliative chemotherapy line III-IV), or in combination with other cytostatic drugs or radiotherapy. In monotherapy (including the purpose radiosensitization): 20-30 mg / kg daily for 3 weeks, daily dose - 2000 mg, or 80 mg / kg, 1 to 3 times of the day (6-7 doses). If, after 4 weeks of therapy continues to be observed a pronounced progression of the disease, treatment should be stopped. For radiosensibilization recommended taking the drug in the last 7 days before the start of radiotherapy.
With sufficient effectiveness of the treatment is administered for an unlimited time. The average maintenance dose - 500-2000 mg. Development of anemia does not require interruption of treatment course provided adequate therapy.
In dermatological diseases average dose - 1-2 grams per day, single dose - 500 mg every 6 hours (pustular psoriasis) or single (common psoriasis) for 7-10 days, then break for 4 days. Drug interactions
Against the background of uricosuric agents increase the risk of developing nephropathy. Drugs that cause pathological changes in the blood, increase leukopenia and / or thrombocytopenia, if these drugs have the same effect as hydroxycarbamide in leukocytes and platelets. Other drugs that cause depression of bone marrow function, or potentiate the effect of radiation therapy and additive depress bone marrow function. With the introduction of live virus vaccines may be increased side effects or decreased antibody production, inactivated vaccines - reduction of production of antiviral antibodies.
