Expiration date: 05/2025

Composition and form of issue:

Tablets, film-coated, 1 tablet contains:

diosmin 0, 45 g

hesperidin 0, 05 g

Excipients:

core — gelatin magnesium stearate microcrystalline starch glycolate sodium talc 

shell-polyethylene glycol 6000 magnesium stearate hydroxypropylmethylcellulose sodium lauryl sulfate titanium dioxide iron oxide red iron oxide yellow 

in a contour shell packing 10 or 15 PCs per cartons 2, 3, 4, 5, 6, 7, 8 or 9 packs.

Description of dosage form:

Tablets, coated with orange-pink, biconvex, oblong with rounded ends, with a risk. Two layers are visible on the cross section.

Pharmacokinetics:

T1/2 is 11 hours Excreted the gastrointestinal tract and kidneys.

Description of pharmacological action:

It reduces the stretching of veins, increases their tone and reduces venous stagnation reduces permeability, fragility of capillaries and increases their resistance improves microcirculation and lymph flow. With systematic use reduces the severity of clinical manifestations of chronic venous insufficiency of the lower extremities of organic and functional nature.

Indications:

• venous insufficiency of the lower extremities of functional and organic nature (feeling of heaviness in the legs, pain, convulsions, trophic disorders)
  
• acute and chronic hemorrhoids.
  

Contraindications:

• hypersensitivity to the drug components
  
• lactation.
  

Side effect:

Dyspepsia, vegetative lability.

Dosage and administration:

Inside. In case of venous insufficiency on the table 1-2. in the day (at noon and in the evening with food). In acute hemorrhoids-6 table. per day for the first 4 days, then 4 table. per day for 3 days.

Special instruction:

During pregnancy, the use is possible (experiments have not shown teratogenic effects until now there have been no reports of any undesirable effects when using the drug in pregnant women), when lactation-not recommended because of the lack of data on the drug in breast milk. In case of exacerbation of hemorrhoids, the appointment of this drug does not replace the specific treatment of other anal disorders. The duration of treatment should be short. If short therapy does not have a positive effect, it is necessary to conduct a proctological study and review the therapy used.