Expiration date: 02/2026
Structure and Composition:
Film-coated tablets. 1 tablet contains clomipramine hydrochloride 25 or 75 mg
Excipients: lactose, corn starch Colloidal anhydrous silica stearic acid, talc, magnesium stearate, glycerol (85%) hydroxypropyl vinylpyrrolidone / titanium acetate dioxide sucrose crystal PVP K30 Disperse Yellow 15093 ansted (iron oxide yellow (EEC172) 5% + titania 95% ( EES171) polyethylene glycol 8,000 (macrogol 8,000), MCC
The solution for intravenous and intramuscular administration. 1 vial contains clomipramine hydrochloride 25 mg
Excipients: glycerol water for injections
in 2 ml ampoules in a cardboard pack of 10 vials.
Dosage and administration:
Before starting therapy should be corrected hypokalemia.
Dosage regimen and mode of administration of the drug is determined individually, taking into account the patient's condition. The goal of treatment is to achieve an optimal effect when using the lowest possible doses and their gentle increase. It should be particularly careful when increasing the dose in elderly patients and adolescents, who are generally more sensitive to the drug Anafranil than patients of intermediate age groups.
Inside, in / in (in the form of infusions), V / m.
Depression, obsessive-compulsive syndromes and phobias
The initial daily dose is 75 mg administered drug Anafranil 25 mg 2-3 times a day, or Anafranil SR 75 mg 1 time a day (preferably in the evening). Then, during the first week of treatment, the dose was gradually increased, for example, at 25 mg every several days (depending on tolerance), to achieve the daily dose is 100-150 mg. In severe cases, the daily dose may be increased to a maximum of 250 mg. After the state of improvement is reached, the patient is transferred to a maintenance dose, 50-100 mg of component (Table 2-4. Anafranil drug or Table 1. Anafranil CP preparation).
Panic attacks, agoraphobia
The initial dose of the drug Anafranil is 10 mg / day. Then, depending on the tolerability of the drug Anafranil, the dose was increased to achieve the desired effect. Anafranil daily dose of the drug varies greatly and can range from 25 to 100 mg. If necessary, may increase the dose to 150 mg / day. It is recommended not to stop the treatment for at least 6 months, decreasing slowly during the time a maintenance dose of the drug.
Cataplexy, accompanying narcolepsy
The daily dose of Anafranil drug is 25-75 mg.
Chronic pain syndromes
The mode set individually. Anafranil daily dose of the drug varies greatly and can range from 10 mg to 150 mg. It should take into account the concomitant analgesic drugs and the possibility of reducing the use of the latter.
Elderly patients. The initial dose is 10 mg / day. Then slowly, over about 10 days, the daily dose is increased to an optimal level, which is 30-50 mg.
Children and adolescents
Obsessive-compulsive syndromes
The initial dose is 25 mg / day. During the first 2 weeks gradually increase the dose, based on tolerability to achieve a daily dose of 100 mg, or the calculated rate of 3 mg / kg - depending on whether the dose is less. Over the next few weeks, the dose is gradually increased to continue to achieve a daily dose of 200 mg, or the calculated rate of 3 mg / kg - depending on whether the dose is less.
nocturnal enuresis
The initial daily dose of Anafranil drug for children aged 5-8 years is 20-30 mg for children aged 9-12 years - 25-50 mg for children over 12 years - 25-75 mg. The use of higher doses indicated for patients who have completely no clinical effect after 1 week of treatment. Usually the whole daily dose of the drug administered in one go after dinner, but when involuntary urination is noted in the early hours of the night, the dose of the drug Anafranil appointed earlier -. In the 16 hours after achieving the desired effect, treatment should be continued for 1-3 months gradually reducing the dose of the drug Anafranil.
Injection
V / m injections
Begin treatment with the administration of 25-50 mg (the contents of the 1-2 Amp.), Then increase the daily dose to 25 mg (1 amp.) To achieve a daily dose of 100-150 mg (4-6 Amp.). Once improvement will be noted, the number of injections was gradually reduced by substituting their supportive care with oral drug forms.
In / Infusion
Treatment starts with a / in the drip of 50-75 mg (2-3 ampoules content.) 1 time per day. To prepare the infusion solution uses 250-500 ml of isotonic solution of sodium or glucose solution infusion duration -. 1.5-3 hours during the infusion should be closely monitored patients for early detection of possible adverse reactions. Particular attention should be given to control blood pressure, since may develop orthostatic hypotension. Upon reaching Anafranil distinct improvements introduced in / for another 3-5 days. Then, to maintain the achieved effect on the admission of the drug inside 2 tab. 25 mg is usually equivalent to 1 amp. Anafranil preparation containing 25 mg. With a view to the gradual transition of infusion therapy to the supporting oral administration of the drug, can first transfer the patient to the / m introduction.
The maximum therapeutic dose - 150 mg / day.
