Expiration date: 06/2025
Pharmacokinetics:
Pantogam rapidly absorbed from the gastrointestinal tract, it passes through the blood-brain barrier, the highest concentrations are in liver, kidney, skin and the stomach wall. Do not metabolized and excreted unchanged within 48 hours: 67.5% of the dose is excreted in the urine, 28.5% - with the feces.
Description of the pharmacological actions:
The spectrum of action Pantogam due to the presence in its structure of gamma-aminobutyric acid (GABA). The mechanism of action is due to a direct effect of the drug on GABA B receptor-channel complex. It has neuroprotective and anticonvulsant effect. Increases resistance to cerebral hypoxia and exposure to toxic substances, it stimulates anabolic processes in neurons, combines moderate sedation with a mild stimulating effect, reduces the excitability of the motor, activates the mental and physical performance. Improves GABA metabolism in chronic alcohol intoxication and after ethanol withdrawal. Is able to inhibit the acetylation reaction involved in the inactivation mechanisms of procaine (Novocain) and sulfonamides, and thus a prolonging action of the latter. It causes inhibition of pathologically elevated cystic and reflex detrusor tone.
Dosage:
INSTRUCTIONS (for information professionals) on the application of the drug Pantogamum (PANTOHAMUM) Tablets
Approved
Pharmacological State Committee May 14, 1999
Chemical name - the calcium salt of (R) 4 - [(2,4-dihydroxy-3,3-dimethylbutyryl) amino] butanoic acid
Description
white tablets.
pharmacological properties
pharmacodynamics
The spectrum of action pantogam due to the presence in its structure of GABA. The mechanism of action is due to a direct effect on pantogam GABA B receptor complex. The drug increases the brain's resistance to hypoxia and exposure to toxic substances, it stimulates anabolic processes in neurons, combines moderate sedation with a mild stimulating effect, has an anticonvulsant effect, reduces the excitability of the motor. Activates mental and physical performance. Cerebro-pantogam specific action related to his neurometabolic, neuroprotective and neurotrophic properties. Promotes normalization of GABA in chronic alcohol intoxication and the subsequent lifting of ethanol. Exhibits analgesic effect. Is able to inhibit the acetylation reaction involved in the mechanisms of inactivation of novocaine and sulfonamides, and thus a prolonging action of the latter. It causes inhibition of pathologically elevated cystic and reflex detrusor tone. Pantogam-toxic, does not cause allergenic, teratogenic and embryotoxic action.
Pharmacokinetics
Pantogam rapidly absorbed from the gastrointestinal tract, it passes through the blood-brain barrier, the highest concentrations are in liver, kidney, in the wall of the stomach and skin. The drug is not metabolized and excreted unchanged within 48 hours, 67.5% of the dose is excreted by the kidneys, 28.5% is excreted in the faeces.
Testimony
Pantogam used for therapeutic and prophylactic purposes in adults and children with disorders of higher cerebral functions of various origins.
Adults Pantogamum prescribed in treatment of cerebrovascular insufficiency, caused by arteriosclerotic changes in cerebral vessels, with the initial forms of senile dementia, residual organic lesions of the brain in adulthood and the elderly.
Pantogam indicated for schizophrenia with cerebral organic insufficiency in combination with neuroleptics, antidepressants, when extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system (myoclonus epilepsy, Huntington's chorea, hepatolenticular dystrophy, Parkinson's and other diseases), as well as in chronic extrapyramidal neuroleptic syndrome ( hyperkinetic and akinetic) as a proofreader at the adverse effect of antipsychotic drugs and prophylactic simultaneously as a "cover therapy."
Pantogam prescribed for epilepsy with mental retardation processes in conjunction with anticonvulsants.
Pantogam used in the complex therapy and the effects of neuroinfections TBI.
Pantogam recommended for psycho-emotional overload, reducing the mental and physical performance, to improve concentration and memory.
Babies Pantogamum appointed from the first days of life with perinatal encephalopathy, mental retardation of varying severity, with developmental delay (mental, verbal, motor, or a combination thereof), with various forms of cerebral palsy, stuttering (mainly clonic form). The drug is used in combination with anticonvulsants, sometimes alone for the treatment of epilepsy, particularly polymorphic attacks and small seizures.
In urological practice Pantogamum used in adults and children from 2 years with urination disorders of various etiologies and clinically manifests as pollakiuria, urgency, imperative urinary incontinence, enuresis.
Contraindications
Hypersensitivity to the drug, acute severe kidney disease, pregnancy (I term).
Dosing and Administration
Pantogam taken orally 15-30 minutes after eating. Single dose for adults is usually 0.25-1 g daily dose - 1.5-3 g single dose for children - 0.25-0.5 g daily dose - 0,75-3 course of treatment 1 -4 months, sometimes up to 6 months. After 3-6 months may conduct re-treatment.
In schizophrenia in combination with neuroleptics, antidepressants, tranquilizers in the dose of from 0.5 g to 3 g per day. The course of treatment - 1-3 months. In epilepsy in combination with anticonvulsants at a dose of 0.75 g to 1 g per day. The course of treatment up to 1 year or more. When extrapyramidal neuroleptic syndrome in combination with ongoing therapy, the daily dose of 3 grams, treatment for several months. When extrapyramidal hyperkinesis in patients with inherited diseases of the nervous system in combination with the study medication from 0.5 g to 3 g per day. The course of treatment up to 4 months or more.
When neuroinfections and consequences of traumatic brain injury of 0.25 g 3 to 4 times a day.
For disaster recovery and at high loads and asthenic conditions associated with old age, Pantogamum appoint 0.25 g three times a day.
Children with different pathologies of the nervous system following doses are recommended based on age: children first year of 0.5-1 g per day, up to 3 years - 1.5 -2 grams per day, for children from 3 to 15 years - 2, 5-3, the purpose of the drug Tactics: escalating doses for 7-12 days, receive a maximum dose for 15 -40 days and the gradual reduction in dose pantogam within 7-8 days. The course of treatment 30-90 days, with a mandatory break in between, followed by a reception pantogam and any other nootropic drugs for 1-3 months. Given the nootropic drug action its reception held in morning and afternoon hours.
When urination disorders adult appoint Pantogamum -1 0.5 g 2-3 times a day. Babies 0,25-0,5 g daily dose of 25 -50 mg / kg. Course of treatment 1-3 months.
Side effects
Allergic reactions (rhinitis, conjunctivitis, skin rashes). In this case, preparation cancel or reduce the dose.
Interaction
Prolonging effect of barbiturates, it enhances the effects of anticonvulsants to prevent side effects of phenobarbital, finlepsin, neuroleptics. pantogam effect is enhanced in combination with glycine, ksidifonom. Potentiates the action of local anesthetics (novocaine).
Special instructions
In the context of long-term treatment is not recommended use of the drug with other nootropic and stimulating agents.
Release Form
50 tablets of 0.5 g and 0.25 in glass jars.
Storage conditions
In a dry, dark place at room temperature.
Shelf life: 3 years
Attention of consumers! Medicines should be kept out of reach of children and use up to the date indicated on the packaging.
INSTRUCTION for medical use of the drug Pantogamum syrup 10% (PANTOHAMUM sirupus 10%)
APPROVED
Pharmacological State Committee of the Russian Ministry of Health February 28, 2001
Chemical name - the calcium salt of (R) 4 - [(2,4-dihydroxy 3,3-dimethylbutyryl?) Amino] butanoic acid
Description
Colorless or slightly yellowish liquid sweet taste with a fruity odor.
Composition
Pantogam, glycerin, sorbitol, food, food citric acid, sodium benzoate, aspartame, food aromatic essence, purified water.
pharmacological properties
pharmacodynamics
The mechanism of action pantogam due to the presence in its structure of gamma-aminobutyric acid, which acts directly on GAMKBretseptor-channel complex. The drug increases the brain's resistance to hypoxia and exposure to toxic substances, it stimulates anabolic processes in neurons, combines moderate sedation with a mild stimulating effect, has an anticonvulsant effect, reduces the excitability of the motor. It improves mental and physical performance. The drug has neurometabolic, neuroprotective and neurotrophic properties. Promotes normalization of GABA in chronic alcohol intoxication and the subsequent lifting of ethanol. Exhibits analgesic effect.
Pharmacokinetics
Pantogam rapidly absorbed from the gastrointestinal tract, it penetrates the BBB. The drug is not metabolized and is excreted unchanged within 48 hours: 67.5% of the dose is excreted by the kidneys, 28.5% is excreted in the faeces.
Testimony
Pantogam used for therapeutic and prophylactic purposes in adults and children with disorders of the brain functions of various origins.
Adults Pantogamum prescribed in treatment of cerebrovascular insufficiency, caused by arteriosclerotic changes in cerebral vessels, with the initial forms of senile dementia, residual organic lesions of the brain in adulthood and the elderly.
Pantogam shown in the treatment of: patients with cerebral organic disease (schizophrenia), and extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system (myoclonus epilepsy, chorea Getingtona, hepatolenticular dystrophy, Parkinson's disease and others)
