Expiration date: 06/2026

Active substance: Idebenone

Description pharmaceutical form:

Capsules - yellow size

The contents of capsules - granules comprising granules and powder of yellow or yellow-orange and orange with white patches.

Pharmacokinetics:

Rapidly absorbed from the gastrointestinal tract, Cmax plasma levels achieved after 4 h after administration. It penetrates through the BBB in large quantities and distributed in brain tissues. Not accumulates even after prolonged use.

Report mostly kidneys.

Description of the pharmacological actions:

Improves metabolic processes in the brain by the reduction of consumption of glucose and ATP, to improve blood flow and oxygen supply of brain tissue. It promotes the elimination of lactate increases neurophysiological reactions of brain structures. As a powerful antioxidant slows lipid peroxidation and thereby prevents neuronal membranes and mitochondria from damage. It possesses nootropic effect in combination with psychoactive effect and neuroprotective properties. From the first days of the drug is antiastenicheskoe, psychostimulant and antidepressant effects. Mnemotropnoe and nootropic effect Nobena seen, usually after 20-25 days of treatment.

It is advisable to use in patients with organic CNS disorders, and emotional lability. Accumulated some experience proving the effectiveness of the use of idebenone in the treatment of Alzheimer's disease.

Testimony:

• various manifestations of cerebrovascular insufficiency (psycho-organic syndrome), caused by disturbance of cerebral circulation and age involutional changes in the brain
  
• cerebroasthenic disorders of the vascular, traumatic, psychogenic (neurasthenia) and combined etiology, manifested in the form of: impaired memory and / or attention, reducing intellectual productivity and overall activity, emotional instability, asthenia, astenodepressivnyh and moderately severe depression, headaches, dizziness, noise in the ears.
  

Contraindications:

• idiosyncrasy
  
• severe renal insufficiency.
  

Application of pregnancy and breastfeeding:

When pregnancy and breast-feeding Caution should be exercised.

Side effect:

Allergic reactions, disturbance of sleep, mental excitement, headache, indigestion.

Drug Interactions:

Not installed.

Dosage and administration:

Inside, after a meal. 1 caps. (30 mg), 2-3 times a day, the last reception -. 17 hours duration course of therapy is 1.5-2 months, depending on the severity of symptoms is performed in the course of 2-3 years.

Overdose:

Treatment: the appointment of activated charcoal, symptomatic therapy.

Special instructions:

Do not take during transport drivers and others whose profession requires quick mental and motor responses.