Expiration date: 09/2027
NEUROURIDIN® H IS A COMBINATION OF NEUROTROPIC SUBSTANCES URIDINE MONOPHOSPHATE AND CHOLINE.
Components of Neurouridin® They help to reduce the intensity of pain syndrome, including in the cervical, thoracic and lumbar spine, and restore damaged nerve fibers.
The content of biologically active substances in 1 capsule (daily dosage):
Name of the biologically active substance One capsule contains, mg % of an adequate level of consumption*
Uridine-5-monophosphate disodium salt 200 -
Choline 100 20
* - % of the adequate level of consumption according to the "Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control)" (Appendix 5).
Nutritional value of 1 capsule: energy value 2.00 kJ/1.00 kcal
The properties of the product are determined by the properties of the components that make up its composition:
Uridine monophosphate (UMF) is the most important nucleotide necessary to maintain metabolic processes (metabolism) in nervous tissue. UMF is involved in the processes of growth and development of nerve cells (neurons), the formation of nerve myelin sheaths.1 UMF promotes the formation of new connections between neurons and improves the processes of interaction between them due to the formation of molecules that transmit nerve impulses from cell to cell, acetylcholine and dopamine. Participates in the regulation of pain sensitivity. The analgesic effect of UMF is realized through direct blockade of the pain impulse, as well as suppression of the production of inflammatory molecules formed during tissue damage.5,6 Uridine monophosphate is of particular importance for the restoration (regeneration) of damaged nerve fibers. Under the influence of UMF, the production of the myelin sheath of the nerve is activated, which provides protection of the nerve fiber and better conduction of the nerve impulse, as a result of which the conduction of nerve impulses improves, sensitivity improves and the intensity of pain in the affected tissues decreases.2,5,6
UMF affects the dopaminergic systems of the brain, contributes to a beneficial effect on the psycho-emotional sphere, improves mood, general well-being and increases stress resistance.1
An important function of UMF is its role in maintaining memory processes and cognitive processes (memorization and learning). This is achieved due to the enhanced formation of connections between neurons and improved interaction processes between them due to the formation of molecules that transmit nerve impulses from cell to cell, acetylcholine and dopamine.1,2
UMF helps protect cells from hypoxia (oxygen starvation), increase glycogen synthesis and increase the body's energy potential, reduce fatigue and increase muscle strength.
Nerve cells do not have their own energy resources to produce nucleotides. The provision of nerve cells with uridine is carried out through the blood flow from other cells, as well as with food and additives containing uridine-5-monophosphate. When peripheral nerves are affected, the need for uridine monophosphate increases. Therefore, its entry into the body from the outside is of crucial importance for maintaining the functions of the nervous system and the processes of restoration (regeneration) of nerve cells and fibers.5,6
Choline is one of the main components of the membranes of brain cells and the myelin sheaths of nerve fibers. Choline is necessary for the production of acetylcholine, which is involved in the function of excitability and transmission of nerve impulses. Choline helps to improve the transmission of neuromuscular signals, increase the rate of transmission of impulses along nerve fibers. Choline is also involved in pain regulation processes, complementing the analgesic effect of UMF. Choline is essential for maintaining brain and nervous system functions such as memory, perception, and mood.7
Components of Neurouridin® They contribute to:
• pain reduction
• normalization of nerve impulse transmission and reduction of pain intensity in affected tissues (including joints and spine)
• reduction of muscle discomfort in the cervical, thoracic and lumbar spine and improvement of mobility in the spine and joints
• repair damaged nerve fibers and reduce the risk of further damage to nerve tissue
• reducing muscle hypoxia and increasing muscle strength
• reducing fatigue and fatigue
• improve memory, thinking and attention
• increased stress tolerance
Literature
1. Arpad Dobolyi, Gabor Juhasz, Zsolt Kovacs and Julianna Kardos Siaw. Uridine Function in the Central Nervous System. / Current Topics in Medicinal Chemistry. 2011, 11, 1058-1067.
2. Lei Wanga, Meredith A. Albrechta et al. Dietary supplementation with uridine-5 -monophosphate (UMP), a membrane phosphatide precursor, increases acetylcholine level and release in striatum of aged rat. Brain Res. 2007 February 16; 1133(1): 42-48.
3. Holguin S, Huang Y, Liu J, Wurtman R. Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats. Behav Brain Res. 2008 Aug 5;191(1):11-6.
4. Negrao L, Nunes P; Portuguese Group for the Study of Peripheral Neuropathy. Uridine monophosphate, folic acid and vitamin B12 in patients with symptomatic peripheral entrapment neuropathies. Pain Manag. 2016;6(1):25-9.
5. Negrao L., Almeida P., Alcino S., et al. Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies./Pain Manag. 2014, 4(3):191-6.
6. Vieira CL, Vasconcelos BC, Leao JC, Laureano Filho JR. Effect of the use of combination uridine triphosphate, cytidine monophosphate, and hydroxycobalamin on the recovery of neurosensory disturbance after bilateral sagittal split osteotomy: a randomized, double-blind trial. / Int. J. Oral Maxillofac Surg. 2016 Feb; 45(2):186-93.
7. Phosphatidylcholine Monograph Alternative Medicine Review Volume 7, Number 2 2002
Luciana Paoletti, Claudia Elena et al. Role of Phosphatidylcholine During Neuronal Differentiation. Life, 2011, 63(9): 714-720.
Yan Zheng, Yanping Li, Eric B Rimm. Dietary phosphatidylcholine and risk of all-cause and cardiovascularspecific mortality among US women and men./ Am J Clin Nutr 2016;104:173-80.
LL-1496-RU 20230523V1.1
Packaging and release form
Capsules weighing 765 mg - 20 pcs per pack.
Composition
uridine-5-monophosphate disodium salt, choline bitartrate; capsule (gelatin; dyes: iron oxide yellow, iron oxide red); anti-caking agents: magnesium oxide, amorphous silicon dioxide, magnesium salt of stearic acid (magnesium stearate).
Indications
It is recommended as a dietary supplement - an additional source of choline containing uridine monophosphate disodium salt.
Contraindications
individual intolerance to the components, pregnancy, breast-feeding.
Method of administration and dosage
For adults, take 1 capsule daily with plenty of water. The duration of admission is 3-4 weeks. If necessary, the reception can be continued. It is recommended to consult a doctor before use.
Special instructions
Biologically active food additive (dietary supplement)
It is not a medicinal product.
It is recommended to consult a doctor before use.
It does not affect the ability to drive vehicles. It is not addictive and does not cause drowsiness.
Storage temperature
from 15℃ to 25℃
