Expiration date: 01/2026

Pharmacological action

Sedative, physiological sleep normalizing, adaptogen, normalizing biological rhythms. Normalizes circadian rhythms. Increases the concentration of GABA and serotonin in the midbrain and hypothalamus, alters the activity of piridoksalkinaza involved in the synthesis of GABA, dopamine and serotonin. Regulates the cycle of sleep-waking, diurnal changes in locomotor activity and body temperature, has a positive effect on intellectual-mnestic functions of the brain, the emotional-personal sphere. Does the biological rhythm and normalization of night sleep. Improves sleep quality, reduces the frequency of attacks of headaches, dizziness, improves mood. Speed of falling asleep, reduces the number of night probujdeni improves fitness after the morning awakening, does not cause the feeling of lethargy, weakness and fatigue upon awakening. Makes dreams more vivid and emotionally rich. Organism adapt to rapid change time zones, reduces stress response, regulates neuroendocrine function.

Interaction

Do effect preparations oppressive Central nervous system, and beta-blockers. Not recommended in conjunction with hormone drugs, are incompatible with MAO inhibitors.

Storage conditions

T=+(15-25)C

Testimony

Sleep disorders, normalization of biological rhythms.

Contraindications

Hypersensitivity expressed by the human kidney, leukemia, lymphoma, Hodgkin's disease, myeloma, diabetes mellitus, chronic renal failure.

Side effects

When used in physiological doses side effects are rare. In patients receiving melatonin described allergic reactions, swelling (in the first week of admission), headache, nausea, vomiting, diarrhea, and morning drowsiness.

Method of application and dosage

Inside, 30–40min before bedtime. Adults 0, 5–1 tablets 1 time a day. As an adaptogen when changing time zones—1 day before the flight and in the next 2-5 days—on 1 tab. a day. The maximum daily dose — 2 tab. a day.