Expiration date: 07/2025

Product: tablets coated with 100 mg

Description: yellow coated tablets with a biconvex surface, two layers are visible on the cross section.

Composition: one tablet contains: active substance: amantadine hydrochloride – 100 mg, excipients: lactose monohydrate, starch 1500 (corn starch partially pregelatinized), croscarmellose sodium, talc, stearic acid, potato starch, Opadry II (contains: polyvinyl alcohol partially hydrolyzed, macrogol 3350, talc, titanium dioxide E 171, aluminum varnish quinoline yellow E 104, iron oxide yellow E 172).

Pharmacotherapeutic group: Antiparkinsonian agents. Adamantane derivatives.

Indications for use

Parkinson's disease, Parkinson's syndrome.

Dosage and administration

Parkinson's disease, Parkinson's syndrome: amantadine is prescribed in an initial dose of 100 mg daily for the first week, then the dose increases to 100 mg twice a day. The required dose should be established depending on the severity of the symptoms of parkinsonism and tolerability of the drug. A dose greater than 200 mg per day may provide some additional effect, but is associated with an increased risk of toxicity. Do not exceed a dose of 400 mg per day. The daily dose should be increased gradually, at intervals of not less than one week. Since patients older than 65 years, as a rule, have reduced renal function and, therefore, higher concentrations of amantadine in plasma, these patients should be assigned the lowest dose, leading to the desired effect.

Cancellation of amantadine should be carried out gradually, that is, reducing the dose twice at intervals of one week. Abrupt withdrawal of amantadine can exacerbate the symptoms of parkinsonism, regardless of the patient's response to the therapy.