Expiration date: 05/2026

Structure and Composition:

1 ml injection solution contains zuclopenthixol decanoate (Viscoleo in vegetable oil) 200 mg in the package 1 or 10 to 1 ml ampoules.

Pharmachologic effect:

Blocks dopamine receptors in the brain.

Indications:

Acute and chronic schizophrenia and others. Psychotic disorders, particularly hallucinations, paranoid delusions, disturbances of thought state of agitation, increased anxiety, hostility, aggressiveness (maintenance therapy).

Contraindications:

Acute poisoning with alcohol, barbiturates, opiates, comatose states.

Application of pregnancy and breastfeeding:

Contraindicated. Nursing mothers should stop breast-feeding.

Side effect:

Chance of extrapyramidal disorders, tardive dyskinesia, neuroleptic malignant syndrome, somnolence, dizziness, dry mouth, accommodation disturbance, urinary retention, constipation, tachycardia, orthostatic hypotension, changes in liver function tests.

Drug Interactions:

It enhances the effect of alcohol, barbiturates and other CNS depressants reduces -. Levodopa and other adrenergic substances.. It reduces the effect of antihypertensive guanetidina and its analogues. The risk of extrapyramidal disorders increase metoclopramide and piperazine. It can be mixed with Clopixol -acuphase (co-injection).

Dosage and administration:

V / m in the upper outer quadrant of the gluteal region. The dosage and the interval between injections are determined individually in accordance with the condition of the patient. Depot Clopixol 200 mg / ml: maintenance therapy is usually administered 200-400 mg (1-2 ml) every 2-4 weeks if necessary - in higher doses or at shorter intervals when the volume of the solution (200 mg / ml) was more 3.2 ml is preferable to use a greater concentration of the solution (500 mg / ml). Depot Clopixol 500 mg / ml: typically administered at 250-750 mg (0.5-1.5 mL) every 1-4 weeks. In the transition from oral to Clopixol Depot oral daily dose (in mg) multiplied by 8 V / m administered one dose every 2 weeks during the first week of oral administration should continue, but at a reduced dosage. In the transition from Clopixol -acuphase simultaneously with the last injection administered 200-400 mg (1-2 ml) Clopixol Depot, repeated injections - one every 2 weeks, if necessary - increase the dose or shorten the interval between infusions.

Precautionary measures:

With caution is prescribed for seizures, chronic hepatitis, cardiovascular disease parties, driving a car, etc. Mechanisms. When long-term therapy, especially at high doses, careful monitoring of the patient.

Clopixol
(Zuclopenthixol)
Depot