Expiration date: 07/20262

International nepatentovanoe name: Clozapine 

Pharmaceutical group

Antipsychotics - derivatives dibenzodiazepine

Synonyms

Azaleptin, Alemoksan, clozapine, leponeks

Composition

The active substance-clozapine.

Indications

Acute and chronic forms of schizophrenia, mania, manic-depressive psychosis, various psychotic states, psychomotor agitation for psychosis, aggression, sleep disorder.

Interaction with other drugs

Do effect sedatives, narcotic, analgesic and snotvornyhsredstv alcohol. It weakens the effect of bowel levodopy.Vsasyvanie worsens when taking antacids and cholestyramine.

Contraindications:

Diseases of the hematopoietic system, alcoholic and toxic psychosis, myasthenia gravis, pregnancy, lactation. (Breastfeeding excluded)

Side effect

Muscle weakness, drowsiness, confusion, dry mouth, paresis of accommodation, tachycardia, decreased blood pressure, dizziness, flattening of the T wave on the ECG, hyperthermia central genesis, exacerbation of chronic and latent infection foci, granulocytopenia.

Overdose:

Symptoms: Tachycardia, bradycardia, heart rhythm disturbances, hallucinations, anxiety, drowsiness, difficulty Dahania.lechenie: Immediately call "ambulance"

Special instructions:

Limited clozapine should be used in severe liver disease, kidney and cardiovascular system, increased tendency to seizures, epilepsy, angle-closure glaucoma, prostatic hypertrophy, intestinal atony, intercurrent febrile zabolevaniyahs sindromom.Vo time of treatment should not drive a vehicle or perform work requiring increased vnimaniya.Neobhodim periodic control over the appearance of the picture krovi- granulocytopenia treatment immediately discontinued.

dosage form

Tablets 100mg, 25mg tablets