Expiration date: 12/2026

The composition and form of issue:

1 ml of solution for infusion contains metronidazole 5 mg box of 1 bottle.

1 tablet of 250 or 500 mg, in bottles of dark glass 20 PCs.

Pharmacokinetics:

Almost completely absorbed after oral administration. Simultaneous eating does not affect the suction. After ingestion of 200 mg, the maximum concentration in plasma (about 5 µg/ml) occurs in about 1-2 h protein binds less than 10% of the drug. Rapidly distributed in the body.

Indications:

Infections caused by anaerobic pathogens: wound infection, infection of the respiratory system, urinary tract, intestines prevention of anaerobic infections before surgery on the bowel trichomoniasis, amoebiasis, giardiasis, Crohn's disease.

Contraindications:

Diseases of the hematopoietic system, acute organic lesions of the Central nervous system.

Application of pregnancy and breast-feeding:

Contraindicated.

Side effects:

Loss of appetite, bad taste in the mouth, nausea, vomiting, diarrhea, headache, dark urine, leukopenia, polyneuropathy, urticaria, itching.

Method of application and dose:

Parenteral adults and children over 12 years: 500 mg (100 ml of infusion solution)/3 times a day, to begin the introduction with 1 g (200 ml). Children under 12 years: 20 mg/kg of body weight per day (3 admission). Parenteral injected for 20-30 minutes in the form of drip infusion with isotonic sodium chloride solution or glucose solution. Parenteral administration is used only in the case of acute and severe infections or in cases where oral introduction is not possible. Oral: trichomoniasis, 250 mg 2 times a day for 7-10 days or 2 g once. Sexual partners should be treated simultaneously. When nonspecific bacterial vaginitis po 500 mg 2 times a day for 7 days 2 g and 2 g on the third day of treatment. In acute amoebic dysentery and amoebic liver abscess adult: 2 g daily for 2-3 days, children 35-50 mg/kg of body weight per day (in 3 divided doses) for 5 days. In asymptomatic intestinal amebiasis adults: 750 mg 3 times a day for 10 days. Giardiasis adults 2 g once daily for 3 days children — 25-40 mg/kg / day (in 2 doses) for 7 days. Ulcerative gingivitis adults: 250 mg 3 times a day for 3 days. Anaerobic bacterial infections adults: 500 mg 3 times a day, children 20 mg/kg of body weight per day (3 admission). Prophylactically with operations adult 1 g 2 hours before surgery, then 500 mg 3 times a day for 2 -3 days children 25 mg/kg 2 hours before surgery then 20 mg/kg / day (in 3 divided doses) for 2-3 days. In Crohn's disease adults: 500 mg 2 times a day, children 20 mg/kg / day (2 admission).

Precautions:

In severe liver failure should reduce the dose. It is necessary to control the cellular composition of the blood. Caution should be exercised when driving vehicles or operating machinery. When drinking alcohol it may develop a reaction, such alcoholocaust.The composition and form of issue:

1 ml of solution for infusion contains metronidazole 5 mg box of 1 bottle.

1 tablet of 250 or 500 mg, in bottles of dark glass 20 PCs.