Expiration date: 08/2022

Structure and Composition:

1 tablet contains metoclopramide hydrochloride 10 mg in blisters of 50 pcs., In a cardboard bundle one package.

1 ml solution for injection - 5 mg in 2 ml ampoules, in a cardboard bundle 5 pcs.

Pharmachologic effect:

Blocks dopamine (D2) and serotonin (5-HT3) receptors inhibits chemoreceptors trigger zone of the brain stem. Has a regulating and normalizing effect on the tone and motility of the gastrointestinal tract, accelerates gastric emptying, increases peristalsis of the small intestine without causing diarrhea.

It stimulates the secretion of prolactin.

Pharmacokinetics:

Rapidly absorbed from the gastrointestinal tract. Bioavailability is 80 ± 15%. Cmax in the blood is observed within 1-2 hours T1 / 2 is 2.5-6 hours, with impaired renal function -.. Up to 14 hours Passes through the placental barrier, BBB and enters the breast milk. Excreted mainly in urine (about 85%) for 72 hours in an unmodified form and in the form of conjugates.

Clinical Pharmacology:

The effect is a 1 h after ingestion, after 10-15 minutes - after the / m, and a few minutes later with a / in the introduction. Effect lasts from 30 minutes to 6 hours (depending on route of administration).

Testimony:

Vomiting, nausea of ??various origins, atonia and hypotonia of the stomach and intestines, including postoperative, biliary dyskinesia, flatulence, reflux esophagitis gastric ulcer and duodenal ulcer (in the complex therapy) conducting X-ray gastrointestinal studies (to increase peristalsis).

Contraindications:

Hypersensitivity, bleeding from the stomach, pyloric stenosis, mechanical intestinal obstruction, perforation of the stomach or intestines, pheochromocytoma, extrapyramidal disorders, epilepsy, tumors prolaktinzavisimye, children up to 6 years (Table), pregnancy.

Application of pregnancy and breastfeeding:

Contraindicated during pregnancy. At the time of treatment should stop breastfeeding.

Side effect:

From the nervous system and sensory organs: headache, dizziness, fatigue, drowsiness, depression, rarely - a spasm of facial muscles, hyperkinesis, spasmodic torticollis (usually held immediately after discontinuation of the drug), agitation, irritability, anxiety, restlessness, parkinsonism and dyskinesia (long-term use, often in the elderly).

From the digestive tract: constipation / diarrhea, rarely - dry mouth.

Other: allergic reactions, infants, edema, galactorrhea, gynaecomastia, menstrual disorders (rare).

Drug Interactions:

Effect weaken anticholinesterase agents. It enhances the effects of alcohol and CNS depressants, the absorption of tetracycline, ampicillin, paracetamol, aspirin, levodopa. It reduces absorption of digoxin and cimetidine. Not to be combined with antipsychotics, because of increased risk of extrapyramidal disorders.

Dosage and administration:

Inside, 30 minutes before meals with a little water, adults - 5-10 mg 3-4 times a day for children older than 6 years - 5 mg 1-3 times a day. In the absence of the effect of the combination treatment is carried out (inside, in / m or / in). The maximum single dose for adults - 20 mg daily - 60 mg.

In / in, in / m, adult to 1020 mg 1-3 times a day for children older than 6 years - 2.5-5 mg 1-3 times a day, 2-6 years - 0.5-1 mg / kg / 1-3 day in reception. Prevention and treatment of nausea and vomiting due to taking cytostatics: 2 mg / kg body weight 30 minutes before application of cytostatic agents or irradiation, if necessary repeating the introduction 2-3 hours before performing X-ray gastrointestinal studies:. 10-20 mg per adult 5- 15 min prior to the study.

Patients with clinically significant hepatic and renal failure - an initial dose reduced in 2 times, follow depends on the individual patient's response.

Overdose:

Symptoms: hypersomnia, disorientation, extrapyramidal disorder.

Treatment: discontinuation symptoms disappear on their own within 24 hours, if necessary - treatment holinoblokatorami and antiparkinsonian agents.

Precautionary measures:

To use caution in patients with arterial hypertension, Parkinson's disease, abnormal liver and kidney function, patients with asthma, the elderly, children. Children up to 6 years is prescribed in drops or parenterally.

Should not be used during the drivers of vehicles and people skills relate to the high concentration of attention.

It is necessary to abstain from alcohol during treatment.

Metoclopramide