Expiration date: 02/2025

Structure and Composition:

The solution for oral and external application

Active substance (per):

Dimethyloxobutylphosphonylmethylate 15 g

adjuvant: Purified water - 100 ml

in orange glass bottles of 100 ml In the paper cartons 1 bottle.

Description pharmaceutical form:

Colourless or yellowish, transparent or opalescent liquid with a distinctive odor.

Characteristic:

Means, normalizing KHS.

Pharmacokinetics:

Dimephosphon after a single dose is absorbed adequately, easily penetrates through the blood-tissue barriers and distributed to the various organs and tissues, and the Cmax in the blood is observed within the first hour after administration of the drug after 3 hours after administration Cmax is determined in the brain, heart and spleen. Three days after a single injection of dimephosphone its trace concentrations remain in the body. Displayed Dimephosphon mostly unchanged in the urine in an amount of 11-15% (up to 70% of the output quantity is allocated during the first 12 hours). Since feces derived less than 0.5%.

Description of the pharmacological actions:

Dimephosphon antiatsidoticheskie displays, membrane, anti-inflammatory and antioxidant properties, normalizes blood flow and metabolism of the brain tissue, reduces cardiac and pulmonary failure, improves the regulation of blood circulation, including cerebral.

Antiatsidoticheskoe action is realized due to the intensification of renal and pulmonary mechanisms regulating acid-base balance, enhance intraorganic blood flow and tissue metabolism, Dimephosphon also reduces the content of lactic and pyruvic acids in brain tissue.

Dimephosphon stabilizes cell membranes, restoring the responsiveness of cerebral vessels, improving the function of the cerebral hemispheres and brain stem, reduces the depth of impaired consciousness and restores the sleep-wake cycle, the reflexes, the arc of which are closed by stem sections, reduces the severity of pyramidal, cerebellar, vestibular, visual and auditory disorders.

Antioxidant action is carried out by preventing the activation of lipid peroxidation and increase the activity of antioxidant enzymes in the brain tissue.

Dimephosphon enhances energy processes in the brain either directly acting directly on the mitochondria, and indirectly, by stimulating the pituitary-thyroid system, increasing consumption of tissues of the thyroid hormones, which is accompanied by the activation energy and catabolic processes in the mitochondria of cells. Shows properties of certain neurotransmitters (GABA-positive, H-choline and dopaminergic activity).

Dimephosphon reduces cardiac and pulmonary failure, restoring the resistivity of peripheral vascular (arterial and venous).

Dimephosphon improves the regulation of the cerebral circulation, without having pronounced vasodilating effect, but a positive effect on the metabolism of the brain tissue when ischemia, improves venous outflow. Clinical Efficacy of drugs in various forms of cerebrovascular disease is related to its ability to increase the resistance of nerve cells to ischaemia with a decrease in swelling and, therefore, improvement of microcirculation.

When applied topically Dimephosphon has anti-inflammatory and antiseptic effect, increases the protective function of the skin and mucous membranes.

Testimony:

• Inside, in the complex therapy:
  
• acute and chronic disorders of cerebral circulation
  
• the effects of ischemic and hemorrhagic strokes
  
• traumatic brain injury
  
• plan neurosurgical operations
  
• osteochondrosis
  
• multiple sclerosis
  
• chronic nonspecific lung disease with symptoms of respiratory and cardiopulmonary insufficiency (application Dimephosphon not eliminate asthma attacks and does not affect the frequency of use of aerosol beta-agonists)
  
• vascular dystonia on the parasympathetic type
  
• tserebrovaskulyatornaya chronic failure due to atherosclerosis and hypertension
  
• migraine
  
• Meniere's disease
  
• Respiratory diseases
  
• acidosis
  
• atopic asthma
  
• hay fever.
  

Outer:

infectious and inflammatory and allergic diseases and damage to the skin and mucous membranes: the area of ??the wound sutures and exit site spokes Ilizarovarozhistoe inflammation)

in dermatology - complex treatment of skin disorders (acne, oily seborrhea, rosacea)

prevention of radiation mucositis.

Contraindications:

• epilepsy
  
• chronic renal failure 2-3-th degree (Cl creatinine less than 40 mL / min)
  
• children and adolescents up to 18 years (due to lack of clinical data on its use in this category of patients) with acute and chronic cerebral circulatory disorders, the effects of ischemic and hemorrhagic stroke, traumatic brain injuries, the planned neurosurgical operations, osteochondrosis, multiple sclerosis, chronic non-specific lung disease with symptoms of respiratory and cardiopulmonary diseases, chronic tserebrovaskulyatornoy failure due to atherosclerosis and hypertension, migraine, Meniere's disease
  
• children up to 12 years in vegetative-vascular dystonia of parasympathetic type.
  

Precautions: Dimephosphon well tolerated. When applied to the mucous membranes may cause irritation, in which case you must dilute solution Dimephosphon half.

Application of pregnancy and breastfeeding:

Currently, the use of these drugs in pregnancy is insufficient to assess the teratogenic Dimephosphon.S Dimephosphon this regard should be used during pregnancy and lactation only if the anticipated benefits of its use outweighs the potential risk to the fetus or infant.

Animal studies have not revealed the damaging effect on the embryo and its development.

Side effect:

Diarrhoeal phenomenon, sleepiness and attention concentration deterioration (for 3-4-th day of the drug tested).

Drug Interactions:

Dimephosphon Interactions with other drugs have been identified.

Dosage and administration:

Inside, after eating, squeezed water.

The course of treatment depends on the nature of the disease and lasts from 3 days to 2 months.

In the treatment of the following diseases and conditions:

In acute and chronic cerebrovascular accidents, the consequences of ischemic and hemorrhagic stroke, traumatic brain injury - adults 15 ml (1 tbsp) 3-4 times a day. Duration 2-3 weeks in some cases - up to 6 weeks.

When planned neurosurgical operations - 15 ml (1 tablespoon) for 5 days before and 2 months after operation.

When osteochondrosis - adults 10 ml (1 des.lozhka) 3-4 times a day for 2-3 weeks, the improvement observed in the 8-10-day treatment.

In multiple sclerosis - adults to 100 mg / kg (45 ml) per day (15 ml (1 tablespoon) 3 times a day) for 10 days in the autumn and spring period monthly.

In chronic non-specific lung disease with symptoms of respiratory and cardiopulmonary diseases - adult 15 ml (1 st.lojke) 3-4 times a day. The course - 7-10 days. Application Dimephosphon does not relieve asthma attacks and does not affect the frequency of use of aerosol beta-agonists.

When vegetative-vascular dystonia of parasympathetic type -vzroslym 15 ml (1 tablespoon) 3 times a day for 2-3 weeks, children over 12 years - 50 mg / kg (10-15 ml) 3 times a day for 3 weeks.

In chronic tserebrovaskulyatornoy failure due to atherosclerosis and hypertension - 15 ml (1 tablespoon) 3 times a day for 2-3 weeks.

Migraine - 15 ml (1 tablespoon) 3 times a day for 2-3 weeks.

Meniere's disease - 15 ml (1 tablespoon) 3 times a day for 3 weeks.

In respiratory diseases, acidosis, atopic asthma and hay fever - adults appoint 15-25 ml for children is prescribed in doses of 75-100 mg / kg up to 3 years - 5 ml (1 teaspoon), 3-8 years - 10 ml (1 des.lozhka) over 8 years - 15 ml (1 tablespoon) 3 times a day in severe - 4 times a day for 4-5 weeks. In atopic asthma in conjunction with hay fever is prescribed for 2-3 weeks before the start of deterioration and take throughout the flowering period.

Outwardly.

When an infectious-inflammatory and allergic diseases of the skin and mucous membranes - in the form of dressings, and lotions turundas with the solution daily for 3-14 days.

In the complex treatment of acne wipe the skin 3-4 times a day, in the evening - gadgets.

When erysipelas inflammation smeared area 3 times a day for 3-5 days.

In the area of ??seams and spokes Ilizarov exit seats impose daily gauze impregnated Dimephosphon, for 7-14 days.

For the prevention of radiation mucositis gauze soaked Dimephosphon fit into the projection beams of radiation for 20 minutes before exposure dose.

Overdose:

Symptoms: increased severity of dose-dependent side effects.

Treatment: gastric lavage, the appointment of activated charcoal, symptomatic therapy.

Special instructions:

Effects on ability to drive or vypolnyatraboty requiring higher rate of physical and mental reactions. When the drowsiness in the early days of the drug should refrain from driving motor vehicles and activities that require attention and speed of psychomotor reactions.

It has a bitter taste. Children are encouraged to wash down with milk, fruit juice, sweet tea.