Expiration date: 07/2025

The composition and form of issue: 

Granules for solution preparation for intake. 100g contains:

citric acid is 39, 9 g

potassium bicarbonate 32, 25 g

trinacria citrate anhydrous 27, 85 g

in plastic bags of 200 g in a plastic jar 1 package, complete with measuring spoon, indicator paper and the test calendar.

Effervescent tablets. 1 tablet contains:

citric acid 1197 mg

potassium bicarbonate 967, 5 mg

sodium citrate anhydrous 835, 5 mg

excipients: lactose monohydrate mannitol adipic acid macrogol 6000 sodium saccharin with lemon flavor 

in a plastic tube, 20 PCs in a carton pack of 4 tubes in the kit with indicator paper and the test calendar.

Description pharmaceutical form:

Granules for preparation of solution for the reception inside: coarse-grained, white, with a faint odor.

Effervescent tablets: white, round, flat, faceted, with lemon scent.

Pharmacokinetics:

Bioavailability is about 100 %. Excreted by the kidneys.

Description pharmacological action:

Dissolves and prevents formation of uric acid stones due to the alkalinization of urine to pH 6, 6-6, 8 (if pH of urine within 6, 6-6, 8 significantly increases the dissolution of salts of uric acid). In addition, reduces the excretion of calcium, improves the solubility of calcium oxalate in the urine that inhibits the formation of crystals and thus prevents the formation of calcium-oxalate stones.

Indications:

• dissolution of urate and calcium oxalate stones and prevent their formation
  
• dissolution of mixed mochekislah-oxalate stones (when the content of oxalates less than 25%)
  
• alkalinization of urine in individuals receiving cytotoxic agents or drugs that increase the excretion of uric acid
  
• symptomatic treatment of skin porphyria.
  

Contraindications:

• hypersensitivity
  
• acute and chronic renal failure
  
• metabolic alkalosis
  
• urinary tract infections caused by microorganisms that break down urea
  
• the pH of the urine above 7
  
• the need for compliance with strict salt-free diet (e.g. in severe forms of arterial hypertension).
  

Side effects:

Allergic reactions, edema (sodium retention), metabolic alkalosis, dyspepsia.

Drug interactions:

Simultaneous reception of preparations containing citrates and aluminum, can lead to increased absorption of aluminum. The interval between doses of these drugs should be at least 2 hours.

Can weaken the effect of cardiac glycosides during their combined administration with Bluemarine, in connection with the presence in the composition of the drug potassium. Some drugs that lower blood pressure (aldosterone antagonists, potassium-sparing diuretics, blockers of APF), as well as NSAIDs and analgesics can reduce the excretion of potassium. The possibility of simultaneous reception of such funds is determined by the doctor.

Method of application and dose:

Inside, pre-dissolved in 200 ml of liquid (tea, fruit juices or alkaline mineral water), after meals.

Daily dose of 6-18 g (2-6 scoops) of powder or granular 2-6 effervescent tablets. One scoop provides 3 g of the granulated powder.

The daily dose is evenly distributed throughout the day. The dose is properly chosen in that case, if the pH during the day is around 6, 2-7, 0 (dissolve uric acid stones) 7, 5-8, 5 (for cystine stones) 7, 2-7, 5 (for the treatment of porphyria) at least 7, 0 (in the treatment with cytostatics). If the pH of the urine below this, the dose should be increased if higher to reduce. The duration of treatment is 4-6 months.

Control efficiency (determination of pH of urine) are carried out 3 times a day before taking each dose with the help of indicator paper. The resulting color on the paper is compared for 2 min with a scale and enter the value in the control calendar.

In the presence of cystine stones and the treatment of porphyria to monitor the effectiveness, you should use the special indicator paper with a pH between 7, 2 and 9, 7.

Special instructions:

Average daily dose (12 g granulated powder or 4 effervescent tablets) contains about 1, 5 mg potassium, and 0, 9 g of sodium (should be considered in patients with restriction of consumption of table salt).

Can be used in chronic renal failure, is not accompanied by a delay of potassium ions.

You can assign patients with diabetes mellitus.

Upon dissolution of uric acid stones should not exceed the daily dosage because with increasing pH above 7, 0 is the deposition of phosphates to uric acid crystals, preventing their further dissolution. During treatment should limit intake of foods rich in protein and purine bases and to ensure sufficient fluid intake (at least 1, 5-2 liters).

Storage conditions:

After opening to protect from moisture.