Expiration date: 09/2025

Release form and composition:

The modified-release tablets, film-coated pink color, round, biconcave.

One tablet contains Trimetazidine dihydrochloride 35 mg

Other ingredients: hypromellose, microcrystalline cellulose, colloidal silicon dioxide (Aerosil), magnesium stearate, Opadry II (hypromellose, lactose monohydrate, polydextrose, macrogol, titanium dioxide, iron oxide yellow, red iron oxide).

Pharmachologic effect:

The drug improving myocardial metabolism, and neurosensory organs (inner ear, the retina of the eye) in the conditions of ischemia. It has antianginal, anti-hypoxic action. Directly affecting cardiomyocytes and neurons in the brain, improves their metabolism and function. Cytoprotective effect is due to an increase in energy potential, activation of oxidative decarboxylation and rationalization of consumption of oxygen (increased aerobic glycolysis and fatty acid oxidation blockade). It supports myocardial contractility, prevents a decrease in intracellular ATP and phosphocreatine.

The conditions of acidosis normalizes the functioning of membrane ion channels, prevents the accumulation of calcium and sodium in cardiomyocytes, normalizes intracellular concentration of potassium ions. Reduces intracellular acidosis and phosphate, caused by myocardial ischemia and reperfusion. It prevents the damaging action of free radicals, preserves the integrity of cell membranes, prevents activation of neutrophils in the zone of ischemia increases the electrical potential, reduces the yield of CK cells and the severity of ischemic damage to the myocardium.

When angina reduces the frequency of attacks (it reduces the nitrate consumption). After 2 weeks of treatment, increases exercise capacity, reduced blood pressure drops.

Against the background of the drug in patients with pathology of the upper respiratory tract is improved hearing and vestibular trial results, reduced vertigo and tinnitus.

In vascular pathology eyes on the background of the drug restores the functional activity of the retina.

Pharmacokinetics:

Suction

After oral administration of trimetazidine is rapidly and almost completely absorbed from the gastrointestinal tract. Bioavailability - 90%. The time to reach Cmax plasma -. After 5 hours a single oral dose of trimetazidine 35mg plasma Cmax of about 115 ng / ml.

Distribution

Binding to plasma proteins - 16%. Easily penetrates the blood-tissue barriers.

breeding

T1 / 2 is 6.5 hours is derived from the body by the kidneys (60% - unchanged)..

Testimony:

• Coronary heart disease: prevention of angina attacks (in the complex therapy)
  
• Chorioretinal vascular disorders
  
• Vertigo of vascular origin
  
• Cochle-vestibular disorders ischemic nature (tinnitus, hearing impairment).
  

Dosage and administration:

Assign to 35 mg (1 tab.) 2 times / day. Tablets are inside, while taking the morning and evening meals.

The duration of treatment is determined individually.

Side effects:

From the digestive system: rarely - gastralgia, nausea, vomiting.

Allergic reactions: itching.

Other: rarely - headache, a feeling of palpitations.

Contraindications:

• Renal insufficiency (creatinine clearance t15 ml / min)
  
• Expressed liver function abnormalities
  
• pregnancy
  
• Lactation (breast-feeding)
  
• Child and adolescence to 18 years (effectiveness and safety of the drug have not been established)
  
• Hypersensitivity to the drug.
  

Pregnancy and lactation:

The drug is contraindicated during pregnancy and lactation (breastfeeding).

Special instructions:

The drug is not intended for the relief of angina attacks. In the case of angina attack treatment should be carried out correction.

Effects on ability to drive vehicles and management mechanisms

Use of the drug has no effect on the ability for classes of potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Overdose:

Currently, the cases of drug overdose Angiozyme retard were reported.

Drug Interactions:

Drug Interactions drug Angiozyme retard is not described.

Conditions and terms:

List B. The drug should be stored out of reach of children, dry, dark place at a temperature no higher than 25 ° C. Shelf life - 2 years.