Expiration date: 08/2026
The composition and form of issue:
Tablets. 1 tablet contains:
methylprednisolone 4 mg
auxiliary substances: calcium stearate corn starch lactose sucrose
blistere in 10 PCs in a pack a cardboard 1, 3 or 10 blisters, or in dark glass bottles to 30 PCs. in cardboard pack 1 bottle.
Tablets. 1 tablet contains:
methylprednisolone 16 mg
auxiliary substances: calcium stearate corn starch lactose liquid paraffin sucrose
blistere in 10 PCs., in a cardboard bundle 5 blisters or blistere in 14 PCs. in cardboard pack 1 blister pack or in bottles of dark glass 50 PCs. in cardboard pack 1 bottle.
Tablets. 1 tablet contains:
methylprednisolone 32 mg
auxiliary substances: calcium stearate corn starch lactose liquid paraffin sucrose
in dark glass bottles at 20 or 50 PCs. in cardboard pack 1 bottle.
Description pharmaceutical form:
Pills elliptical shape white color, one side has crosswise 2 notches, the other embossed "UPJOHN" (tab. 4 mg), "UPJOHN 73" (tab. 16 mg), "UPJOHN 176" (tab. 32 mg).
Method of application and dose:
Inside. The dose may vary and should be individualized depending on the nature of the disease and the patient's response to therapy. Initial dose of 4 to 48 mg/day, depending on the nature of the disease. In less severe disease tend to be quite lower doses, although individual patients may require higher doses. High doses may be required in such diseases and conditions as multiple sclerosis (200 mg/day), cerebral edema (200-1000 mg/day) and organ transplantation (up to 7 mg/kg/day). If after a reasonable period of time not received a satisfactory clinical effect, the drug should be discontinued and the patient another type of therapy.
Children dose determined by the physician based on weight or body surface. When adrenal insufficiency — 0.18 mg/kg, or 3.33 mg/m2/day in 3 admission, other evidence — 0,42–1,67 mg/kg or 12.5–50 mg/m2/day in 3 admission.
Elimination of the drug after long-term therapy is recommended gradually. If the treatment produced a good effect, you should pick up a sick individual maintenance dose by gradually reducing the initial dose after a certain period of time until, until you find the lowest dose that maintain the achieved clinical effect. Remember that requires constant monitoring of the dosage regimen of the drug.
Situations may arise, which would require dosage adjustment, such as changes in clinical condition caused by remission or exacerbation of the disease, the individual patient's response to medication and the impact on patient stressful situations not directly related to the underlying disease for which the therapy is aimed in the latter case, you may need to increase the dose of the drug for a certain period of time, depending on the condition of the patient.
Alternating therapy.
Alternating therapy is a dosing regimen in which twice the daily dose of glucocorticosteroids is inserted through the morning. The purpose of this therapy is to achieve the patient taking the drug for a long time, the maximum clinical effect while minimizing certain undesirable effects, such as suppression of the pituitary-adrenal axis, withdrawal of corticosteroids and growth retardation in children.
