Local irritating drugs excite the end of the sensitive nerves, causing local and reflex, improving blood supply and tissue trophism, pain etc. In the mechanism of action also plays the role of the local release of biologically active substances, autacoids is characterized — kinins, histamine, prostaglandins, etc.

The irritation of receptors of the mucous membranes, skin and subcutaneous tissue accompanied by the formation and release of enkephalins, endorphins, dynorphins and other peptides that are of great importance for the perception of pain, changes in vascular permeability, cellular and tissue reactivity, etc. Some "local" funds in varying degrees, are absorbed and may cause systemic effects rezorbtivee to influence various regulatory processes, including neurotransmitter, immune, etc.

Integrated local reflex action of irritating substances is accompanied by vascular dilation (improves trophic tissues and the outflow of fluid) in the areas of application and segments are the internal organs and muscles ("allow" action to pathological processes in these organs), the weakening of the pain emanating from these bodies (the"diversionary" effect). As annoying tools use mustard (a glycoside of mustard sinigrin wetting yellow card in warm water is split by enzyme to merosina has a strong irritating activity allylthiourea), turpentine ointment and liniment, Finalgon, camphor, alcohol, poisons bees and snakes (We have experienced an unexpected side effect, etc.), capsicum plaster and etc. Scope of annoying tools includes arthritis, myositis, neuritis, bruises, sprains, circulatory disorders, etc.