Expiration date: 08/2026
Release form
Tablets, film-coated
Composition
1 tablet contains atorvastatin (calcium salt) 10, 20 or 40 mg
Packaging
30 PCs.
Pharmacological action
Atorvastatin - a lipid lowering drug from the group of statins. On the principle of competitive antagonism statin molecule binds with the part of the receptor of coenzyme A, where it is attached HMG-COA reductase. Another part of the molecule of the statin inhibits the process of turning hydroxymethylglutaryl to mevalonate, an intermediary product in the synthesis of molecules of cholesterol. The inhibition of the activity of HMG-COA reductase leads to a series of sequential reactions that result in reduced intracellular cholesterol content and a compensatory increase in the activity of LDL-receptors and, accordingly, acceleration of catabolism of cholesterol (Xc) LDL.
Testimony
Primary hypercholesterolemia in ineffectiveness of diet, combined hypercholesterolemia and hypertriglyceridemia, heterozygous and homozygous familial hypercholesterolemia with the ineffectiveness of diet.
Contraindications
Liver disease in the active stage, the increase in the activity of serum transaminases more than 3 times of unknown origin, pregnancy, lactation (breastfeeding), hypersensitivity to atorvastatin. Women of reproductive age, not using reliable contraception. Atorvastatin is contraindicated during pregnancy and lactation (breastfeeding).
Application of pregnancy and breastfeeding
Unknown, whether atorvastatin is allocated in breast milk. Given the possibility of adverse events in infants, if necessary, the use of the drug during lactation should decide the issue of termination of breastfeeding. Women of reproductive age during treatment should use adequate methods of contraception. Atorvastatin can be prescribed to women of reproductive age only if the probability of pregnancy they have very low, and the patient informed about the possible risk of treatment for the fetus.
Method of application and doses
The treatment is carried out against the standard diet for patients with hypercholesterolemia. The dose of Atorvastatin is determined individually, depending on the source of cholesterol. Take inside. The initial dose is usually 10 mg 1 time per day. The effect is manifested within 2 weeks and the maximum effect is for 4 weeks. If necessary, the dose can be gradually increased at intervals of 4 weeks or more. The maximum daily dose of Atorvastatin is 80 mg.
Special instructions
Before and during treatment with Atorvastatin, especially if symptoms of liver injury should be monitored indicators of liver function. When the level of activity of transaminases should be monitored until normalization. If the activity of AST or ALT more than 3 times the norm persists, we recommend decreasing the dose or cancellation of Atorvastatin.
Drug interactions
The risk of myopathy during treatment with other medicinal products derived from statins is increased with simultaneous use of cyclosporine, fibrates, erythromycin, antifungal agents belonging to azoles, and Niacin. Simultaneous ingestion of Atorvastatin and suspensions containing magnesium hydroxide and aluminum hydroxide, atorvastatin concentration in plasma decreased by about 35%, but the degree of reduction in Cholesterol levels-LDL is not changed. With simultaneous use of Atorvastatin does not affect the pharmacokinetics of antipyrine (phenazone), therefore interaction with other drugs, metabolized by the same isoenzymes of cytochrome P450 are not expected.
Overdose
Treatment: no specific antidote, symptomatic therapy. Hemodialysis is ineffective.
Storage conditions
In protected from light place, at temperature not above 25 °C.
