• Letizen (Cetirizine)

Expiration date: 06/2024

Structure and Composition:

1 tablet, film-coated, containing 10 mg of cetirizine dichloride in blisters of 10 pcs., In a cardboard unit 1 or 2 packaging.


Round, slightly biconvex tablets of white color, with a notch on one side.

Pharmachologic effect:

Blocks peripheral gistaminove H1-receptor, prevents the development of histamine (dilation and increased permeability of the capillaries, causing the development of edema, urticaria and flushing the excitation of sensory nerve endings, accompanied by itching and pain, contraction of smooth muscles of the respiratory and gastrointestinal tract) effects. At a late stage of an allergic reaction to inhibit the release of histamine and eosinophil migration.


Rapidly absorbed from the gastrointestinal tract (70%), Cmax achieved within 1 hour. Slightly metabolized in the liver and excreted in the urine largely unchanged.

Description of the pharmacological actions:

The action is manifested through 20 minutes, reaching a maximum after 1 hour and lasts for 24 hours.


Seasonal and perennial allergic rhinitis, allergic conjunctivitis, chronic urticaria, angioedema, and others. Allergic diseases.


Hypersensitivity to the drug and to hydroxyzine.

Application of pregnancy and breastfeeding:

Do not be taken in the I trimester of pregnancy, in II-III possibly under strict indications. At the time of treatment should stop breastfeeding.

Side effect:

Cardio-vascular system and blood (blood, hemostasis): hemolytic anemia, thrombocytopenia.

From the digestive tract: nausea, vomiting, abdominal pain, diarrhea, constipation, increased appetite, transient increase in liver transaminases.

From the nervous system and sensory organs: drowsiness, fatigue, weakness, dizziness, headache, dry mouth.

Drug Interactions:

Cl Theophylline reduces and increases the plasma concentration of the drug.

Dosage and administration:

Inside, before or after a meal, washed down with a small amount of liquid, adults and children over 12 years - 10 mg / day, children 6-12 years old (weighing over 30 kg) - 5 mg 2 times a day for children 6 12 years old (weighing less than 30 kg) - 5 mg / day.

In patients with renal insufficiency (Cl creatinine 11-13 ml / min), hemodialysis (Cl creatinine less than 7 ml / min) or hepatic dysfunction - 5 mg / day.


Symptoms: agitation, irritability, drowsiness, urinary retention, tremors, tachycardia, pruritus, rash.

Treatment: gastric lavage, the appointment of activated charcoal, laxatives, symptomatic therapy.

Precautionary measures:

To apply caution in patients on hemodialysis, renal insufficiency of moderate severity, abnormal liver function, the elderly (dosage adjustment is required) and drivers of vehicles and people skills relate to the high concentration of attention. Not recommended simultaneous application of oppressive central nervous system, and the use of alcohol. Do not use in children under 6 years.